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Chapter 31 - Dementia

Published online by Cambridge University Press:  02 January 2025

By
Jeffrey McBride  and
Lokesh Shahani
Edited by
Marsal Sanches  and
Jair C. Soares
Marsal Sanches
Affiliation:
McGovern Medical School, Texas
Jair C. Soares
Affiliation:
McGovern Medical School, Texas
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Summary

As an increasing number of people are living longer and later into life than ever before, neurocognitive disorders, including dementia, are becoming a growing burden on patients, their families, and the overall health care system. Impairments associated with dementia affect the person’s independence to complete daily activities, their social functioning and relationships, and occupational tasks. This chapter provides a summary of basic clinical, epidemiological, and pathophysiological aspects of major neurodegenerative disorders.

Keywords

dementiamajor neurodegenerative disorderAlzheimer’s Diseasecognitive disorders
Type
Chapter
Information
Fundamentals of Clinical Psychiatry
A Practical Handbook
 , pp. 320 - 325
Publisher: Cambridge University Press
Print publication year: 2025

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References

Zissimopoulos, J. M., Tysinger, B. C., St Clair, P. A., et al. The impact of changes in population health and mortality on future prevalence of Alzheimer’s disease and other dementias in the United States. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 2018; 73:S38–S47.CrossRefGoogle ScholarPubMed
Breitner, J. C.. Mild cognitive impairment and progression to dementia: new findings. Neurology 2014; 82:e34–e35.CrossRefGoogle ScholarPubMed
Freedman, V. A., Kasper, J. D.. Cohort profile: the National Health and Aging Trends Study (NHATS). Int J Epidemiol 2019; 48:1044–1045g.CrossRefGoogle ScholarPubMed
Sadock, B. J., Sadock, V. A., Ruiz, P., eds. Kaplan & Sadock’s Synopsis of Psychiatry. 11th ed. Lippincott Williams & Wilkins; 2015.Google Scholar
Gallagher, D., Coen, R., Kilroy, D., et al. Anxiety and behavioral disturbance as markers of prodromal Alzheimer’s disease in patients with mild cognitive impairment. International Journal of Geriatric Psychiatry 2011; 26:166.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed., text rev. APA Publishing; 2022.Google Scholar
Raina, P., Santaguida, P., Ismaila, A., et al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 2008; 148: 379.CrossRefGoogle ScholarPubMed

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