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Chapter 18 - Individual differences in sleep duration and responses to sleep loss

from Section 3 - Sleepphysiology and homeostasis

Published online by Cambridge University Press:  05 November 2013

By
Devon A. Grant  and
Hans P.A. Van Dongen
Edited by
Paul Shaw ,
Mehdi Tafti  and
Michael J. Thorpy
Paul Shaw
Affiliation:
University of Washington, St Louis
Mehdi Tafti
Affiliation:
University of Lausanne
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Albert Einstein College of Medicine, New York
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Summary

During sleep deprivation, the homeostatic sleep drive does not build up as high in the long sleepers as in the short sleepers due to allostatic effects from prior sleep history, and at least in part as a consequence of genetic make-up, there are large individual differences in the cognitive deficits caused by sleep deprivation. A frequently overlooked aspect of trait vulnerability to sleep loss is that ranking of individuals in terms of magnitude of their vulnerability depends on the task they perform. Despite an ongoing, worldwide search for predictors of trait vulnerability to sleep loss, reliable biomarkers have not yet been identified. Handful of genetic polymorphisms has been found to modulate individual vulnerability to sleep deprivation. In summary, healthy adults exhibit systematic individual differences both in sleep duration and in cognitive impairment due to sleep loss.

Keywords

sleep regulationtuberomammilary nucleuslipocalin-type prostaglandin synthaseprostaglandin D2sleepinductionadenosinehematopoietic prostaglandin synthaseknockout mice
Type
Chapter
Information
The Genetic Basis of Sleep and Sleep Disorders , pp. 189 - 196
Publisher: Cambridge University Press
Print publication year: 2013

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