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6 - Alignments

from Part II - Fundamentals of Biological Sequence Analysis

Published online by Cambridge University Press:  28 September 2023

Veli Mäkinen ,
Djamal Belazzougui ,
Fabio Cunial  and
Alexandru I. Tomescu
Veli Mäkinen
Affiliation:
University of Helsinki
Djamal Belazzougui
Affiliation:
Centre de Recherche sur l’Information Scientifique et Technique (CERIST), Algiers
Fabio Cunial
Affiliation:
Broad Institute, Massachusetts
Alexandru I. Tomescu
Affiliation:
University of Helsinki
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Summary

An alignment of two sequences aims to highlight how much in common the two sequences have. In computational biology, an alignment is a prediction of the evolutionary steps between the two sequences. Different costs for such steps can be assigned, and then one can seek for an optimal alignment. This chapter gives a comprehensive introduction to the dynamic programming algorithms developed for various alignment formulations.

Type
Chapter
Information
Genome-Scale Algorithm Design
Bioinformatics in the Era of High-Throughput Sequencing
 , pp. 83 - 128
Publisher: Cambridge University Press
Print publication year: 2023

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  • Alignments
  • Veli Mäkinen, University of Helsinki, Djamal Belazzougui, Centre de Recherche sur l’Information Scientifique et Technique (CERIST), Algiers, Fabio Cunial, Broad Institute, Massachusetts, Alexandru I. Tomescu, University of Helsinki
  • Book: Genome-Scale Algorithm Design
  • Online publication: 28 September 2023
  • Chapter DOI: https://doi.org/10.1017/9781009341257.009
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  • Alignments
  • Veli Mäkinen, University of Helsinki, Djamal Belazzougui, Centre de Recherche sur l’Information Scientifique et Technique (CERIST), Algiers, Fabio Cunial, Broad Institute, Massachusetts, Alexandru I. Tomescu, University of Helsinki
  • Book: Genome-Scale Algorithm Design
  • Online publication: 28 September 2023
  • Chapter DOI: https://doi.org/10.1017/9781009341257.009
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Alignments
  • Veli Mäkinen, University of Helsinki, Djamal Belazzougui, Centre de Recherche sur l’Information Scientifique et Technique (CERIST), Algiers, Fabio Cunial, Broad Institute, Massachusetts, Alexandru I. Tomescu, University of Helsinki
  • Book: Genome-Scale Algorithm Design
  • Online publication: 28 September 2023
  • Chapter DOI: https://doi.org/10.1017/9781009341257.009
Available formats
×