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from Part III - Specific Conditions
Published online by Cambridge University Press: 24 June 2021
SE is defined as 5 minutes or longer of continuous clinical and/or electrographic seizure activity or recurrent seizures without interval recovery; t1 refers to the time point beyond which there is failure of mechanisms responsible for seizure termination or initiation of mechanisms which lead to abnormally prolonged seizures, and t2 refers to the time point beyond which there are long term consequences due to neuronal injury, death, and alteration of neuronal networks. Semiologically, SE can be classified as with or without prominent motor features. Convulsive SE may evolve into NCSE in a significant minority after convulsive activity ceases. NCSE may be diagnosed on EEG in a significant minority of critically ill patients. EPC may not be associated with ictal activity on surface EEG. De novo absence SE may be seen in older individuals in the setting of abrupt benzodiazepine withdrawal. They may have a previous or family history of IGE.
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