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Chapter 20 - Progressive Multifocal Leukoencephalopathy: The Early Years

Published online by Cambridge University Press:  27 July 2023

Robert Laureno
Robert Laureno
Affiliation:
Georgetown University, Washington DC
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Summary

Raymond Adams recognized a patient as having a clinically unique disease. On autopsy the brain revealed unique neuropathology. On microscopy Byron Waksman, an immunologist, noted inclusion bodies in oligodendroglia. Astrom, Mancall, and Richardson named the entity Progressive Multifocal Leukoencephalopathy (PML). Gabriele Zu Rhein and Sam Chou used electron microscopy to demonstrate virus in the cells. Later Zu Rhein provided fresh brain to Druard Walker. He and Billie Padgett grew the virus in cell culture to prove that PML was in fact a viral disease. These many investigators contributed to the early understanding of this disease.

Keywords

Progressive multifocal leukoencephalopathyByron WaksmanGabriele Zu RheinDruard WalkerBillie PagettSam Chou
Type
Chapter
Information
Insights into Clinical Neurology , pp. 97 - 100
Publisher: Cambridge University Press
Print publication year: 2023

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References

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