Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-26T19:18:00.001Z Has data issue: false hasContentIssue false

Chapter 6 - The Effect of Age on Male Fertility and the Health of Offspring

Published online by Cambridge University Press:  24 May 2020

By
Allan Pacey  and
Sarah Martins da Silva
Edited by
R. John Aitken ,
David Mortimer  and
Gabor Kovacs
R. John Aitken
Affiliation:
University of Newcastle, New South Wales
David Mortimer
Affiliation:
Oozoa Biomedical Inc, Vancouver
Gabor Kovacs
Affiliation:
Epworth Healthcare Melbourne
Get access

Summary

This chapter provides detailed practical information about testing for sperm antibodies and interpretation of the results of various antibody tests. It also briefly reviews our knowledge about anti-sperm antibodies (ASA) in males and females and outlines several lines of evidence regarding the predisposing factors for sperm immunity in men and women.

Keywords

advanced paternal ageassisted reproductive technologysemen analysissperm qualitychild healthcongenital birth defectspsychiatric spectrum disorders
Type
Chapter
Information
Male and Sperm Factors that Maximize IVF Success , pp. 73 - 82
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Office for National Statistics (2017) Births by Parents’ Characteristics in England and Wales: 2016. London: Office for National Statistics. www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/bulletins/birthsbyparentscharacteristicsinenglandandwales/2016Google Scholar
Khandwala, Y. S., Zhang, C. A., Lud, Y. and Eisenberg, M. L. (2017) The age of fathers in the USA is rising: an analysis of 168,867,480 births from 1872 to 2015. Hum Reprod 32:2110–2116.Google Scholar
Johnson, S. L., Dunleavy, J., Gemmell, N. J. and Nakagawa, S. (2015) Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis. Ageing Res Rev 19:22–33.CrossRefGoogle ScholarPubMed
Verón, G. L., Tissera, A. D., Bello, R., Beltramone, F., Estofan, G., Molina, R. I., et al. (2018) Impact of age, clinical conditions, and lifestyle on routine semen parameters and sperm kinematics. Fertil Steril 110:68–75.Google Scholar
Almeida, S., Rato, L., Sousa, M., Alves, M. G. and Oliveira, P. F. (2017) Fertility and sperm quality in the aging male. Curr Pharm Des 23:4429–4437.Google Scholar
Samavat, J., Natali, I., Degl’Innocenti, S., Filimberti, E., Cantini, G., Di Franco, A., et al. (2014) Acrosome reaction is impaired in spermatozoa of obese men: a preliminary study. Fertil Steril 102:1274–1281.CrossRefGoogle ScholarPubMed
Pacey, A. (2018) Is sperm DNA fragmentation a useful test that identifies a treatable cause of male infertility? Best Pract Res Clin Obstet Gynaecol 53:11–19.Google Scholar
Jenkins, T. G., Aston, K. I., Pflueger, C., Cairns, B. R. and Carrell, D. T. (2014) Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet 10(7):e1004458.CrossRefGoogle ScholarPubMed
Paoli, D., Pecora, G., Pallotti, F., Faja, F., Pelloni, M., Lenzi, A., et al. (2019) Cytological and molecular aspects of the ageing sperm. Hum Reprod 34:218–227.CrossRefGoogle ScholarPubMed
Ford, W. C., North, K., Taylor, H., Farrow, A., Hull, M. G. and Golding, J. (2000) Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 15:1703–1708.CrossRefGoogle Scholar
de La Rochebrochard, E. and Thonneau, P. (2003) Paternal age >or=40 years: an important risk factor for infertility. Am J Obstet Gynecol 189:901–905.Google Scholar
Dunson, D. B., Colombo, B. and Baird, D. D. (2002) Changes with age in the level and duration of fertility in the menstrual cycle. Hum Reprod 17:1399–1403.Google Scholar
Gunes, S., Hekim, G. N., Arslan, M. A. and Asci, R. (2016) Effects of aging on the male reproductive system. J Assist Reprod Genet 33:441–454.Google Scholar
Johannes, C. B., Araujo, A. B., Feldman, H. A., Derby, C. A., Kleinman, K. P. and McKinlay, J. B. (2000) Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts Male Aging Study. J Urol 163:460–463.Google Scholar
Araujo, A. B., Mohr, B. A. and McKinlay, J. B. (2004) Changes in sexual function in middle-aged and older men: longitudinal data from the Massachusetts Male Aging Study. J Am Geriatr Soc 52:1502–1509.Google Scholar
Sartorius, G. A. and Nieschlag, E. (2010) Paternal age and reproduction. Hum Reprod Update 16:65–79.Google Scholar
Slama, R., Bouyer, J., Windham, G., Fenster, L., Werwatz, A. and Swan, S. H. (2005) Influence of paternal age on the risk of spontaneous abortion. Am J Epidemiol 161:816–823.CrossRefGoogle ScholarPubMed
Urhoj, S. K., Jespersen, L. N., Nissen, M., Mortensen, L. H. and Nybo Andersen, A. M. (2014) Advanced paternal age and mortality of offspring under 5 years of age: a register-based cohort study. Hum Reprod 29:343–350.CrossRefGoogle ScholarPubMed
de La Rochebrochard, E., de Mouzon, J., Thépot, F. and Thonneau, P. (2006) French National IVF Registry (FIVNAT) association. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilisation in France. Fertil Steril 85:1420–1424.Google Scholar
Belloc, S., Cohen-Bacrie, P., Benkhalifa, M., Cohen-Bacrie, M., De Mouzon, J., Hazout, A., et al. (2008) Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination. Reprod Biomed Online 17:392–397.Google Scholar
Frattarelli, J. L., Miller, K. A., Miller, B. T., Elkind-Hirsch, K. and Scott, R. T. Jr. (2008) Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproduction technology cycles. Fertil Steril 90:97–103.Google Scholar
Whitcomb, B. W., Turzanski-Fortner, R., Richter, K. S., Kipersztok, S., Stillman, R. J., et al. (2011) Contribution of male age to outcomes in assisted reproductive technologies. Fertil Steril 95:147–151.CrossRefGoogle ScholarPubMed
Dain, L., Auslander, R. and Dirnfeld, M. (2011) The effect of paternal age on assisted reproduction outcome. Fertil Steril 95:1–8.Google Scholar
Beguería, R., García, D., Obradors, A., Poisot, F., Vassena, R. and Vernaeve, V. (2014) Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers? Hum Reprod 10:2114–2122.CrossRefGoogle Scholar
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., et al. (2012) The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod 27:2908–2917.CrossRefGoogle Scholar
Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magusson, G., et al. (2012) Rate of de novo mutations and the importance of father’s age to decrease risk. Nature 488:471–475.Google Scholar
Goriely, A. and Wilkie, A. O. (2012) Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. Am J Hum Genet 90:175–200.Google Scholar
Yang, Q., Wen, S. W., Leader, A., Chen, X. K., Lipson, J. and Walker, M. (2007) Paternal age and birth defects: how strong is the association. Hum Reprod 22:696–701.Google Scholar
Green, R. F., Devine, O., Crider, K. S., Olney, R. S., Archer, N., Olshan, A. F., et al. (2010) National Birth defects Prevention Study. Association of paternal age and risk for major congenital and anomalies from the National Birth Defects Prevention Study, 1997 to 2004. Ann Epidemiol 20:241–249.Google Scholar
Janecka, M., Mill, J., Basson, M. A., Goriely, A., Spiers, H., Reichenberg, A., et al. (2017) Advanced paternal age effects in neurodevelopmental disorders – review of potential underlying mechanisms. Transl Psychiatry 31(7):e1019.CrossRefGoogle Scholar
D’onofrio, B. M., Rickert, M. E., Frans, E., Kuja-Halkola, R., Almqvist, C., Sjolander, A., et al. (2014) Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psych 71:432–438.Google Scholar
Khandwala, Y. S., Baker, V. L., Shaw, G. M., Stevenson, D. K., Lu, Y. and Eisenberg, M. L. (2018) Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study. BMJ 363:k4372.CrossRefGoogle ScholarPubMed
Wu, C., Lipshultz, L. I. and Kovac, J. R. (2016) The role of advanced paternal age in modern reproductive medicine. Asian J Androl 18:425.Google Scholar
National Institute for Health and Clinical Excellence (2013) Fertility: Assessment and Treatment for People with Fertility Problems. www.nice.org.uk/guidance/cg156/evidence/full-guideline-pdf-188539453Google Scholar
Association of Biomedical Andrologists; Association of Clinical Embryologists; British Andrology Society; British Fertility Society; Royal College of Obstetricians and Gynaecologists (2008) UK guidelines for the medical and laboratory screening of sperm, egg and embryo donors Hum Fertil 11:201–210.Google Scholar
Ghuman, N. K., Mair, E., Pearce, K. and Choudhary, M. (2016) Does age of the sperm donor influence live birth outcome in assisted reproduction? Hum Reprod 31:582–590.Google Scholar
Smith, K. R. (2015) Paternal age bioethics. J Med Ethics 41:775–779.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×