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Chapter 5 - Lifestyle Factors and Sperm Quality

Published online by Cambridge University Press:  24 May 2020

By
Ciara Wright
Edited by
R. John Aitken ,
David Mortimer  and
Gabor Kovacs
R. John Aitken
Affiliation:
University of Newcastle, New South Wales
David Mortimer
Affiliation:
Oozoa Biomedical Inc, Vancouver
Gabor Kovacs
Affiliation:
Epworth Healthcare Melbourne
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Summary

This chapter considers the effect of paternal age on semen analysis, sperm function and DNA damage, as well as age-related impact on male fertility, both natural conception (time to conception (TTC)) and assisted reproduction technology (ART) outcomes, including intrauterine insemination (IUI), in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI). The effects of advanced paternal age (APA) on health of offspring, including congenital birth defects, paternal age effect (PAE) disorders, and psychiatric spectrum disorders (schizophrenia, autism and dyslexia) are also discussed. Increasing male age results in a steady decline in semen quality, reduced sperm function, including acrosome reaction, proteomic and genomic expression and increase in sperm nuclear DNA damage. However, lack of a clear definition of advanced paternal age, and a variable impact on relevant endpoints (conception, miscarriage, live birth, child health) make discussions challenging for healthcare professionals when counselling patients regarding specific male age-related risks.

Type
Chapter
Information
Male and Sperm Factors that Maximize IVF Success , pp. 59 - 72
Publisher: Cambridge University Press
Print publication year: 2020

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References

Levine, H., Jorgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., et al. (2017) Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Repro Update 23:646–659.Google Scholar
Salas-Huetos, A., Bullo, M. and Salas-Salvado, J. (2017) Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 23:371–389.Google Scholar
Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J. and Gharagozloo, P. (2016) Causes and consequences of oxidative stress in spermatozoa. Reprod Fert Dev 28:1–10.Google Scholar
La Vignera, S., Condorelli, R., Vicari, E., D’Agata, R. and Calogero, A. E. (2012) Diabetes mellitus and sperm parameters. J Androl 33:145–153.Google Scholar
Esmaeili, V., Shahverdi, A. H., Moghadasian, M. H. and Alizadeh, A. R. (2015) Dietary fatty acids affect semen quality: a review. Andrology 3:450–461.CrossRefGoogle ScholarPubMed
Xia, W., Chiu, Y. H., Williams, P. L., Gaskins, A. J., Toth, T. L., et al. (2015) Men’s meat intake and treatment outcomes among couples undergoing assisted reproduction. Fert Steril 104:972–979.Google Scholar
Chiu, Y. H., Afeiche, M. C., Gaskins, A. J., Williams, P. L., Mendiola, J., et al. (2014) Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men. Hum Reprod 29:1575–1584.Google Scholar
Jensen, T. K., Swan, S. H., Skakkebaek, N. E., Rasmussen, S. and Jorgensen, N. (2010) Caffeine intake and semen quality in a population of 2,554 young Danish men. Am J Epidem 171:883–891.CrossRefGoogle Scholar
Hatch, E. E., Wesselink, A. K., Hahn, K. A., Michiel, J. J., Mikkelsen, E. M., et al. (2018) Intake of sugar-sweetened beverages and fecundability in a North American preconception cohort. Epidemiology 29:369–378.Google Scholar
Wright, C., Milne, S. and Leeson, H. (2014) Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility. Reprod Biomed Online 28:684–703.CrossRefGoogle ScholarPubMed
Zhao, J., Dong, X., Hu, X., Long, Z., Wang, L., et al. (2016) Zinc levels in seminal plasma and their correlation with male infertility: a systematic review and meta-analysis. Sci Reports 6:22386.Google ScholarPubMed
Fallah, A., Mohammad-Hasani, A. and Colagar, A. H. (2018) Zinc is an essential element for male fertility: a review of Zn roles in men’s health, germination, sperm quality, and fertilization. J Reprod Infert 19:69–81.Google ScholarPubMed
Mortimer, D. (2018) The functional anatomy of the human spermatozoon: relating ultrastructure and function. Mol Hum Reprod DOI 10.1093/molehr/gay040Google Scholar
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T. and Hart, R. J. (2014) Antioxidants for male subfertility. Cochrane database of systematic reviews (Online) CD007411.CrossRefGoogle Scholar
Stoffaneller, R. and Morse, N. L. (2015) A review of dietary selenium intake and selenium status in Europe and the Middle East. Nutrients 7:1494–1537.CrossRefGoogle ScholarPubMed
Mistry, H. D., Broughton Pipkin, F., Redman, C. W. and Poston, L. (2012) Selenium in reproductive health. Am J Obst & Gyn 206:21–30.Google Scholar
Tvrda, E., Peer, R., Sikka, S. C. and Agarwal, A. (2015) Iron and copper in male reproduction: a double-edged sword. J Assist Reprod Gen 32:3–16.Google Scholar
Majzoub, A. and Agarwal, A. (2018) Systematic review of antioxidant types and doses in male infertility: benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Arab J Urol 16:113–124.Google Scholar
Greco, E., Iacobelli, M., Rienzi, L., Ubaldi, F., Ferrero, S. and Tesarik, J. (2005) Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 26:349–353.CrossRefGoogle ScholarPubMed
Greco, E., Romano, S., Iacobelli, M., Ferrero, S., Baroni, E., et al. (2005) CSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Hum Reprod 20:2590–2594.CrossRefGoogle Scholar
Hosseini, B., Nourmohamadi, M., Hajipour, S., Taghizadeh, M., Asemi, Z., et al. (2018) The effect of omega-3 fatty acids, EPA, and/or DHA on male infertility: a systematic review and meta-analysis. J Diet Supp 1–12.Google Scholar
Zhang, Y. Y., Liu, W., Zhao, T. Y. and Tian, H. M. (2017) Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: a meta-analysis of randomized clinical trials. J Nut Health Age 21:187–192.CrossRefGoogle ScholarPubMed
Foran, J. A., Carpenter, D. O., Hamilton, M. C., Knuth, B. A. and Schwager, S. J. (2005) Risk-based consumption advice for farmed Atlantic and wild Pacific salmon contaminated with dioxins and dioxin-like compounds. Environ Health Pers 113:552–556.Google Scholar
Reilly, R., McNulty, H., Pentieva, K., Strain, J. J. and Ward, M. (2014) MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins? Proc Nut Soc 73:47–56.CrossRefGoogle Scholar
Aarabi, M., San Gabriel, M. C., Chan, D., Behan, N. A., Caron, M., et al. (2015) High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism. Hum Mol Gen 24:6301–6313.Google Scholar
Blomberg Jensen, M. (2014) Vitamin D and male reproduction. Nature Rev Endocrin 10:175–186.Google Scholar
Martinez-Bakker, M., Bakker, K. M., King, A. A. and Rohani, P. (2014) Human birth seasonality: latitudinal gradient and interplay with childhood disease dynamics. Proc Biol Sci 281:20132438.Google Scholar
Mushtaq, R., Pundir, J., Achilli, C., Naji, O., Khalaf, Y. and El-Toukhy, T. (2018) Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online 36:459–471.CrossRefGoogle ScholarPubMed
MacDonald, A. A., Herbison, G. P., Showell, M. and Farquhar, C. M. (2010) The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update 16:293–311.CrossRefGoogle ScholarPubMed
Shamloul, R. and Ghanem, H. (2013) Erectile dysfunction. Lancet 381:153–165.Google Scholar
Leisegang, K., Bouic, P. J. and Henkel, R. R. (1989) Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case-controlled male cohort. Am J Reprod Immun (New York) 76:155–163.Google Scholar
Faure, C., Dupont, C., Baraibar, M. A., Ladouce, R., Cedrin-Durnerin, I., et al. (2104) In subfertile couples, abdominal fat loss in men is associated with improvement of sperm quality and pregnancy: a case-series. PloS one 9:e86300.Google Scholar
Gaskins, A. J., Afeiche, M. C., Hauser, R., Williams, P. L., Gillman, M. W., et al. (2014) Paternal physical and sedentary activities in relation to semen quality and reproductive outcomes among couples from a fertility center. Hum Reprod 29:2575–2582.CrossRefGoogle ScholarPubMed
Hajizadeh Maleki, B. and Tartibian, B. (2015) Long-term low-to-intensive cycling training: impact on semen parameters and seminal cytokines. Clin J Sport Med: Official J Can Acad Sport Med 25:535–540.Google Scholar
Zhang, M. H., Zhang, A. D., Shi, Z. D., Wang, L. G. and Qiu, Y. (2015) Changes in levels of seminal nitric oxide synthase, macrophage migration inhibitory factor, sperm DNA Integrity and Caspase-3 in fertile men after scrotal heat stress. PloS one 10:e0141320.Google Scholar
Adams, J. A., Galloway, T. S., Mondal, D., Esteves, S. C. and Mathews, F. (2014) Effect of mobile telephones on sperm quality: a systematic review and meta-analysis. Environ Int 70:106–112.Google Scholar
Li, Y., Lin, H., Li, Y. and Cao, J. (2011) Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses. Fertil Steril 95:116–123.CrossRefGoogle ScholarPubMed
Wesselink, A. K., Wise, L. A., Rothman, K. J., Hahn, K. A., Mikkelsen, E. M., et al. (2016) Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort. Reprod Tox (Elmsford, NY) 62:39–45.Google Scholar
Harlev, A., Agarwal, A., Gunes, S. O., Shetty, A. and du Plessis, S. S. (2015) Smoking and male infertility: an evidence-based review. World J Men’s Health 33:143–160.Google Scholar
Sharma, R., Harlev, A., Agarwal, A. and Esteves, S. C. (2016) Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Eur Urol 70:635–645.CrossRefGoogle ScholarPubMed
Jensen, T. K., Andersson, A. M., Skakkebaek, N. E., Joensen, U. N., Blomberg Jensen, M., et al. (2013) Association of sleep disturbances with reduced semen quality: a cross-sectional study among 953 healthy young Danish men. Am J Epidem 177:1027–1037.Google Scholar
Deng, N., Haney, N. M., Kohn, T. P., Pastuszak, A. W. and Lipshultz, L. I. (2018) The effect of shift work on urogenital disease: a systematic review. Current Urol Rep 19:57.Google Scholar

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