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Chapter 2 - Botulinum Neurotoxin

History of Clinical Development

Published online by Cambridge University Press:  02 November 2023

By
Daniel Truong ,
Deepmala Nandanwar  and
Mark Hallett
Edited by
Daniel Truong ,
Dirk Dressler ,
Mark Hallett ,
Christopher Zachary  and
Mayank Pathak
Daniel Truong
Affiliation:
University of California, Riverside
Dirk Dressler
Affiliation:
Hannover Medical School
Mark Hallett
Affiliation:
National Institutes of Health (NIH)
Christopher Zachary
Affiliation:
University of California, Irvine
Mayank Pathak
Affiliation:
Truong Neuroscience Institute
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Summary

In 1980, Alan B Scott published the use of botulinum neurotoxin type A by injection into extraocular muscles for treatment of strabismus. Use in blepharospasm was published in 1985, and cervical dystonia in 1986, followed by hemifacial spasm and other dystonias, including spasmodic dysphonia, hand dystonia, and conditions such as limb spasticity.

Formulations of neurotoxin type A worldwide include: Botox/onabotulinumtoxinA, Dysport/abobotulinumtoxinA, Xeomin/incobotulinumtoxinA, and a Chinese product marketed under various brand names in Asia. Botulinum neurotoxin type B is marketed as Neurobloc/Myobloc, or rimabotulinumtoxinB. PrabotulinumtoxinA and daxibotuinumtoxinA-Ianm are type A toxins under development.

Keywords

StrabismusAlan B. Scottobotulinum neurotoxinoculinumblepharospasmcervical dystoniahemifacial spasmdystoniaBotoxonabotulinumtoxinANeuroBlocMyoblocrimabotulinumtoxinBXeominincobotulinumtoxinADysport abobotulinumtoxinA prabotulinumtoxinANeuronoxMeditoxinoxibotulinumtoxinA,daxibotulinumtoxinA-IanmDAXXIFY
Type
Chapter
Information
Manual of Botulinum Toxin Therapy , pp. 9 - 12
Publisher: Cambridge University Press
Print publication year: 2023

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References

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