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18 - The acute effects of cannabinoids in patients with psychotic illness

Published online by Cambridge University Press:  05 November 2011

By
Cécile Henquet ,
Andrew Sewell ,
Rebecca Kuepper ,
Mohini Ranganathan  and
Deepak Cyril D’Souza
Edited by
David Castle ,
Robin M. Murray  and
Deepak Cyril D'Souza
David Castle
Affiliation:
University of Melbourne
Robin M. Murray
Affiliation:
Institute of Psychiatry
Deepak Cyril D'Souza
Affiliation:
Yale University, Connecticut
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Summary

This chapter reviews the acute effects of cannabis and cannabinoids in people with psychotic illness. The acute effects of cannabis in schizophrenia patients are reported to include no effects, reductions in anxiety, depression and negative symptoms, increased suspiciousness and variable effects on hallucinations. Tetrahydrocannibinol (THC) transiently exacerbated a range of positive and negative psychotic symptoms, perceptual alternations, cognitive deficits and medication side effects associated with schizophrenia without producing clear beneficial effects. Cannabidiol has been shown to have anxiolytic and antipsychotic effects, leading to the suggestion that cannabidiol may offset some of the adverse effects of THC. In patients with psychotic illness, cannabidiol appears to act like an antipsychotic. Cannabis use and misuse is common in people with schizophrenia. Ongoing clinical trials are likely to provide more definitive evidence regarding the effects of cannabidiol in schizophrenia.

Keywords

bipolar disordercannabinoidscannabismoodendocannabinoid systemcognitive effectscomorbidity
Type
Chapter
Information
Marijuana and Madness , pp. 198 - 209
Publisher: Cambridge University Press
Print publication year: 2011

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