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Chapter 10 - Aging and Environmental Interactions with the Sperm Epigenome

from Section 2 - The Biology of Male Reproduction and Infertility

Published online by Cambridge University Press:  06 December 2023

By
Albert Salas-Huetos  and
Douglas T. Carrell
Edited by
Douglas T. Carrell ,
Alexander W. Pastuszak  and
James M. Hotaling
Douglas T. Carrell
Affiliation:
Utah Center for Reproductive Medicine
Alexander W. Pastuszak
Affiliation:
University of Utah
James M. Hotaling
Affiliation:
Utah Center for Reproductive Medicine
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Summary

The definition of epigenetics has been redefined in the last decades and today is generally accepted as the study of heritable factors, other than DNA base pair coding, that regulate gene expression. In this chapter, we briefly review the main epigenetic factors that exist in spermatozoa (e.g., histone and chromatin modifications, DNA methylation, and noncoding RNAs [ncRNAs]) and underline the associations and effects of aging, adiposity, and some lifestyle and environmental factors on the sperm epigenome. In conclusion, further work needs to be done to establish whether the changes of sperm epigenome triggered by aging, adiposity, diet, and smoking can have not only implications for the reproductive health but also for the future offspring.

Keywords

spermepigeneticsagingobesitylifestyle factorsenvironmental factors
Type
Chapter
Information
Men's Reproductive and Sexual Health Throughout the Lifespan
An Integrated Approach to Fertility, Sexual Function, and Vitality
 , pp. 81 - 86
Publisher: Cambridge University Press
Print publication year: 2023

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