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Chapter 18 - Clinical Fertility Preservation Decision-Making for Prepubertal and Postpubertal Individuals with Male Gametes

from Section 3 - Clinical Evaluation and Treatment of Male Infertility

Published online by Cambridge University Press:  06 December 2023

By
Jerrine Morris ,
Heiko Yang ,
John Lindsey  and
James F. Smith
Edited by
Douglas T. Carrell ,
Alexander W. Pastuszak  and
James M. Hotaling
Douglas T. Carrell
Affiliation:
Utah Center for Reproductive Medicine
Alexander W. Pastuszak
Affiliation:
University of Utah
James M. Hotaling
Affiliation:
Utah Center for Reproductive Medicine
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Summary

Many benign and malignant conditions are treated with fertility-threatening medical or surgical therapies. Fertility preservation is a recourse critical to discuss prior to initiation of these therapies. This chapter describes contemporary and future fertility preservation approaches while also exploring barriers in access to their use as well as key decision-making strategies helpful for clinicians caring for patients with a range of medical conditions.

Keywords

fertility preservationgamete cryopreservationsperm bankingsperm cryopreservationtesticular tissue cryopreservationoocyte cryopreservationovarian cryopreservationegg freezingprepubescent fertilitycanceradolescentchemotherapy
Type
Chapter
Information
Men's Reproductive and Sexual Health Throughout the Lifespan
An Integrated Approach to Fertility, Sexual Function, and Vitality
 , pp. 141 - 153
Publisher: Cambridge University Press
Print publication year: 2023

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References

Zegers-Hochschild, F, Adamson, GD, de Mouzon, J, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology. Fertility and Sterility. 2009;92(5):1520–1524.Google Scholar
Anderheim, L, Holter, H, Bergh, C, Moller, A. Does psychological stress affect the outcome of in vitro fertilization?. Hum Reprod. 2005;20(10):2969–2975.Google Scholar
Klosky, J, Simmons, JL, Russell, KM, et al. Fertility as a priority among at-risk adolescent males newly diagnosed with cancer and their parents. Support Care Cancer. 2015;23(2):333–341.Google Scholar
Barnett, M, McDonnell, G, DeRosa, A, et al. Psychosocial outcomes and interventions among cancer survivors diagnosed during adolescence and young adulthood (AYA): a systematic review. J Cancer Surviv. 2016;10(5):814–831.Google Scholar
Oktay, K, Harvey, B, Partridge, A, et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol. 2018;36(19):1994–2001.Google Scholar
Garcia, MM. Genital gender-affirming surgery: patient care, decision making, and surgery options. In: McAninch, JW, Lue, TF, eds. Smith & Tanagho’s General Urology. 19th ed. McGraw-Hill; 2020:747–768.Google Scholar
Coleman, E, Bockting, W, Botzer, M, et al. Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgend. 2012;13(4):165–232.CrossRefGoogle Scholar
Hembree, W, Cohen-Kettenis, PT, Gooren, L, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society* clinical practice guideline. J Clin Endocrinol Metab. 2017;102(11):3869–3903.Google Scholar
Close, A, Dreyzin, A, Miller, KD, Seynnaeve, BKN, Rapkin, LB. Adolescent and young adult oncology – past, present, and future. CA Cancer J Clin. 2019;69(6):485–496.Google Scholar
National Cancer Institute. SEER Cancer Statistics Review 1975–2017. January 6, 2021. https://seer.cancer.gov/csr/1975_2017/browse_csr.php?sectionSEL=2&pageSEL=sect_02_table.07. Accessed November 1, 2022.Google Scholar
Siegel, R, Miller, KD, Jemal, A. Colorectal cancer mortality rates in adults aged 20 to 54 years in the United States, 1970–2014. JAMA. 2017;318(6): 572–574.CrossRefGoogle ScholarPubMed
Moss, J, Choi, AW, Keeter, MKF, Brannigan, RE. Male adolescent fertility preservation. Fertil Steril. 2016;105(2):267–273.Google Scholar
Schover, L, Brey, K, Lichtin, A, Lipshultz, LI, Jeha, S. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol. 2002;20(7):1880–1889.CrossRefGoogle ScholarPubMed
Flink, D, Sheeder, J, Kondapalli, LA. A review of the oncology patient’s challenges for utilizing fertility preservation services. J Adolesc Young Adult Oncol. 2017;6(1):31–44.Google Scholar
Klosky, J, Randolph, ME, Navid, F, et al. Sperm cryopreservation practices among adolescent cancer patients at risk for infertility. Pediatr Hematol Oncol. 2009;26:252–260.Google Scholar
Patel, P, Kohn, TP, Cohen, J, Shiff, B, Kohn, J, Ramasamy, R. Evaluation of reported fertility preservation counseling before chemotherapy using the Quality Oncology Practice Initiative Survey. JAMA Netw Open. 2020;3(7):e2010806.CrossRefGoogle ScholarPubMed
Lawson, A, McGuire, JM, Noncent, E, Olivieri, JF, Smith, KN, Marsh, EE. Disparities in counseling female cancer patients for fertility preservation. J Womens Health (Larchmt). 2017;26(8):886–891.Google Scholar
Yang, H, Ramstein, J, Smith, J. Non-oncologic indications for male fertility preservation. Curr Urol Rep. 2019;20(9):51.CrossRefGoogle ScholarPubMed
Condorelli, M, Demeestere, I. Challenges of fertility preservation in non‐oncological diseases. Acta Obstet Gynecol Scand. 2019;98(5):638–646.CrossRefGoogle ScholarPubMed
Johnson, E, Finlayson, C, Rowell, EE, et al. Fertility preservation for pediatric patients: current state and future possibilities. J Urol. 2017;198(1):186–194.CrossRefGoogle ScholarPubMed
Ataman, LM, Rodrigues, JK, Marinho, RM, et al. Creating a global community of practice for oncofertility. J Glob Oncol. 2016;2(2):83–96.Google Scholar
Meistrich, M. Effects of chemotherapy and radiotherapy on spermatogenesis in humans. Fertil Steril. 2013;100(5):1180–1186.Google Scholar
Frydman, R, Grynberg, M. Male fertility preservation: innovations and questions. Fertil Steril. 2016;105(2):247–248.Google Scholar
Okada, K, Fujisawa, M. Recovery of spermatogenesis following cancer treatment with cytotoxic chemotherapy and radiotherapy. World J Mens Health. 2019;37(2):166–174.Google Scholar
Stahl, P, Stember, DS, Hsiao, W, Schlegel, PN. Indications and strategies for fertility preservation in men. Clin Obstet Gynecol. 2010;53(4):815–827.Google Scholar
Trost, L, Brannigan, R. Fertility preservation in males. In: Gracia, C, Woodruff, TK, eds. Oncofertility medical practice: clinical issues and implementation. Springer Science+Business Media; 2012:27–44.CrossRefGoogle Scholar
T’Sjoen, G, Caenegem, EV, Wierckx, K. Transgenderism and reproduction. Curr Opin Endocrinol Diabetes Obes. 2013;20(6):575–579.CrossRefGoogle Scholar
Adeleye, A, Reid, G, Kao, CN, Mok-Lin, E, Smith, JF. Semen parameters among transgender women with a history of hormonal treatment. Urology. 2019;124:136–141.Google Scholar
Mehta, A, Sigman, M. Management of the dry ejaculate: a systematic review of aspermia and retrograde ejaculation. Fertil Steril. 2015;104(5):1074–1081.Google Scholar
Practice Committee of the American Society for Reproductive Medicine. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril. 2019;112(6):1022–1033.Google Scholar
Adank, M, van Dorp, W, Smit, M, et al. Electroejaculation as a method of fertility preservation in boys diagnosed with cancer: a single-center experience and review of the literature. Fertil Steril. 2014;102(1):199–205.e1.Google Scholar
Tur-Kaspa, I, Segal, S, Moffa, F, Massobrio, M, Meltzer, S. Viagra for temporary erectile dysfunction during treatments with assisted reproductive technologies. Hum Reprod. 1999;14(7):1783–1784.CrossRefGoogle ScholarPubMed
Berookhim, B, Mulhall, JP. Outcomes of operative sperm retrieval strategies for fertility preservation among males scheduled to undergo cancer treatment. Fertil Steril. 2014;101(3):805–811.CrossRefGoogle ScholarPubMed
Benoit, M, Chiles, K, Hsieh, M. The landscape of coverage for fertility preservation in male pediatric patients. Urol Pract. 2018;5(3):198–204.Google Scholar
Jiang, D, Swenson, E, Mason, M, et al. Effects of estrogen on spermatogenesis in transgender women. Urology. 2019;132:117–122.Google Scholar
Schrader, M, Muller, M, Sofikitis, N, et al. “Onco-Tese”: testicular sperm extraction in azospermic cancer patients before chemotherapy – new guidelines? Urology. 2003;61(2):421–425.Google Scholar
Bhattacharya, S, Harrild, K, Mollison, J, et al. Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained infertility: pragmatic randomised controlled trial. BMJ. 2008;337.Google Scholar
Katz, P, Showstack, J, Smith, JF, et al. Costs of infertility treatment: results from an 18-month prospective cohort study. Fertil Steril. 2011;95(3):915–921.Google Scholar
Wu, A, Odisho, AY, Washington, SL, Katz, PP, Smith, JF. Out-of-pocket fertility patient expense: data from a multicenter prospective infertility cohort. J Urol. 2013;191(2):427–432.Google Scholar
Neblett, M, Hipp, H. Fertility considerations in transgender persons. Endocrinol Metab Clin North Am. 2019;48(2):391–402.CrossRefGoogle ScholarPubMed
Mehta, A, Nangia, AK, Dupree, JM, Smith, JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016;105(5):1128–1137.Google Scholar
Goodman, L, Balthazar, U, Kim, J, Mersereau, JE. Trends of socioeconomic disparities in referral patterns for fertility preservation consultation. Hum Reprod. 2012;27(7):2076–2981.Google Scholar
Schenker, J. Assisted reproduction practice: religious perspectives. Reprod Biomed Online. 2005;10(3):310–319.Google Scholar
Quinn, G, Vadaparampil, ST, King, L, et al. Impact of physicians’ personal discomfort and patient prognosis on discussion of fertility preservation with young cancer patients. Patient Educ Couns. 2009;77(3):338–343.Google Scholar
Schover, L, Brey, K, Lichtin, A, Lipshultz, LI, Jeha, S. Oncologists’ attitudes and practices regarding banking sperm before cancer treatment. J Clin Oncol. 2002;20(7):1890–1897.Google Scholar
Anazodo, A, Laws, P, Logan, S, et al. How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care. Hum Reprod Update. 2019;25(2):159–179.Google Scholar
Letourneau, J, Smith, JF, Ebbel, EE, et al. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 2012;118(18):4579–4588.Google Scholar
Ethics Committee of the American Society for Reproductive Medicine. Access to fertility services by transgender persons: an Ethics Committee opinion. Fertil Steril. 2015;104(5):1111–1115.Google Scholar
Baram, S, Myers, SA, Yee, S, Librach, CL. Fertility preservation for transgender adolescents and young adults: a systematic review. Hum Reprod Update. 2019;25(6):696–716.Google Scholar
Martinez, F, International Society for Fertility Preservation–ESHRE–ASRM Expert Working Group. Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting: indications, results and future perspectives. Hum Reprod. 32(9):1802–1811.CrossRefGoogle Scholar
Committee on Bioethics, American Academy of Pediatrics. Informed consent, parental permission, and assent in pediatric practice. Pediatrics, 1995;95(2):314–317.CrossRefGoogle Scholar
Ramstein, J, Halpern, J, Gadzinski, AJ, Brannigan, RE, Smith, JF. Ethical, moral, and theological insights into advances in male pediatric and adolescent fertility preservation. Andrology. 2017;5(4):631–639.Google Scholar
Stein, D, Victorson, DE, Choy, JT, et al. Fertility preservation preferences and perspectives among adult male survivors of pediatric cancer and their parents. J Adolesc Young Adult Oncol. 2014;3(2):75–82.Google Scholar
Zebrack, B, Casillas, J, Nohr, L, Adams, H, Zeltzer, LK. Fertility issues for young adult survivors of childhood cancer. Psychooncology. 2004;13:689–699.Google Scholar
Quinn, G, Knapp, C, Murphy, D, Sawczyn, K, Sender, L. Congruence of reproductive concerns among adolescents with cancer and parents: pilot testing an adapted instrument. Pediatrics. 2012;129(4):e930–e936.Google Scholar
Ginsberg, J, Carlson, CA, Lin, K, et al. An experimental protocol for fertility preservation in prepubertal boys recently diagnosed with cancer: a report of acceptability and safety. Hum Reprod. 2010;25(1):37–41.Google Scholar
Hermann, BP, et al. Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell. 2012;11(5):715–726.Google Scholar
Fayomi, AP, Peters, K, Suhkwani, M, et al. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science. 2019;363(6433):1314–1319.Google Scholar
Hayashi, K, Ohta, H, Kurimoto, K, et al. Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell. 2011;146(4):519–532.Google Scholar
Hayashi, K, Ogushi, S, Kurimoto, K, et al. Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice. Science. 2012;338(6109):971–975.Google Scholar
Eguizabal, C, Montserrat, N, Vassena, R, et al. Complete meiosis from human induced pluripotent stem cells. Stem Cells. 2011;29(8):1186–1195.Google Scholar
Easley, CA, Philips, BT, McGuire, MM, et al. Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep. 2012;2(3):440–446.CrossRefGoogle ScholarPubMed
Liu, W, Schulster, ML, Alukal, JP, Najari, BB. Fertility preservation in male to female transgender patients. Urol Clin North Am. 2019;46(4):487–493.Google Scholar
Kafetsoulis, A, Brackett, NL, Ibrahim, E, Attia, GR, Lynne, CM. Current trends in the treatment of infertility in men with spinal cord injury. Fertil Steril. 2006;86(4):781–789.Google Scholar
Harris, R, Kolaitis, IN, Frader, JE. Ethical issues involving fertility preservation for transgender youth. J Assist Reprod Genet. 2020;37(10):2453–2462.Google Scholar
Wiepjes, C, Nota, NM, Blok, CJM, et al. The Amsterdam Cohort of Gender Dysphoria Study (1972e2015): trends in prevalence, treatment, and regrets. J Sex Med. 2018;15(4):582–590.Google Scholar
de Vries, A, McGuire, JK, Steensma, TD, Wagenaar, ECF, Doreleijers, TAH, Cohen-Kettenis, PT. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics. 2014;134(4):696–704.CrossRefGoogle ScholarPubMed
Wang, Y, Anazodo, A, Logan, S. Systematic review of fertility preservation patient decision aids for cancer patients. Psychooncology. 2018;28(3):459–467.Google Scholar
Gassei, K, Orwig, KE. Experimental methods to preserve male fertility and treat male factor infertility. Fertil Steril. 2015;105(2):256–266.Google Scholar
Meistrich, M, Wilson, G, Mathur, K, et al. Rapid recovery of spermatogenesis after mitoxantrone, vincristine, vinblastine, and prednisone chemotherapy for Hodgkin’s disease. J Clin Oncol. 1997;15(12):3488–3495.Google Scholar
Sonmezer, M, Oktay, K. Fertility preservation of female patients. Hum Reprod Update. 2004;10(3):251–266.Google Scholar

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