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Chapter 5 - Examples of Immunophenotypic Features in Various Categories of Acute Leukaemia

Published online by Cambridge University Press:  30 January 2025

By
Marie-Christine Béné  and
Anna Porwit
Edited by
Anna Porwit  and
Marie Christine Béné
Anna Porwit
Affiliation:
Lunds Universitet, Sweden
Marie Christine Béné
Affiliation:
Université de Nantes, France
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Summary

The term “acute leukemia” actually covers a large number of different diseases. This is mostly related to the lineage involved, yet, even in a single lineage, differences exist according to the differentiation stage where maturation blockade occurred or to the type of chromosomal/molecular anomalies associated with the disease. This chapter provides a guide of how immunophenotypic anomalies, typically identified very early in the diagnosis process, can orient further cytogenetic or molecular investigations, allowing for a faster integrated diagnosis and better focused patient management.

Keywords

flow cytometryacute leukemiamonoblasticpromyelocyticmyeloidlymphoblasticmegakaryoblasticblastic plasmacytoid dendritic cell neoplasmdiagnosisintegrated explorations
Type
Chapter
Information
Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies , pp. 73 - 92
Publisher: Cambridge University Press
Print publication year: 2025

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References

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