Book contents
- Multivariate Biomarker Discovery
- Multivariate Biomarker Discovery
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- Part I Framework for Multivariate Biomarker Discovery
- Part II Regression Methods for Estimation
- 6 Basic Regression Methods
- 7 Regularized Regression Methods
- 8 Regression with Random Forests
- 9 Support Vector Regression
- Part III Classification Methods
- Part IV Biomarker Discovery via Multistage Signal Enhancement and Identification of Essential Patterns
- Part V Multivariate Biomarker Discovery Studies
- References
- Index
7 - Regularized Regression Methods
from Part II - Regression Methods for Estimation
Published online by Cambridge University Press: 30 May 2024
- Multivariate Biomarker Discovery
- Multivariate Biomarker Discovery
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- Part I Framework for Multivariate Biomarker Discovery
- Part II Regression Methods for Estimation
- 6 Basic Regression Methods
- 7 Regularized Regression Methods
- 8 Regression with Random Forests
- 9 Support Vector Regression
- Part III Classification Methods
- Part IV Biomarker Discovery via Multistage Signal Enhancement and Identification of Essential Patterns
- Part V Multivariate Biomarker Discovery Studies
- References
- Index
Summary
Chapter 7 is dedicated to regularized regression methods, which – by penalizing models that are too complex – are capable of providing a reasonable tradeoff between bias and variance. Ridge regression implements L2 regularization, which results in more generalizable models, but does not perform any feature selection. L1 penalty used by the lasso allows, however, for simultaneous regularization and feature selection. The elastic net algorithm combines the two approaches by applying both L1 and L2 penalties, which allows for solutions combining the advantages of both ridge regression and the lasso. The chapter concludes by discussing a general class of Lq-regularized least squares optimization problems.
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- Multivariate Biomarker DiscoveryData Science Methods for Efficient Analysis of High-Dimensional Biomedical Data, pp. 114 - 125Publisher: Cambridge University PressPrint publication year: 2024