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Chapter 14 - Trust and Psychopharmaca:

Neuromodulation of the Signaling Pathways Underlying Trust Behavior

from Part IV - Neuromolecular Level of Trust

Published online by Cambridge University Press:  09 December 2021

By
Mary R. Lee ,
Apoorva Veerareddy  and
Frank Krueger
Edited by
Frank Krueger
Frank Krueger
Affiliation:
George Mason University, Virginia
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Summary

Psychopharmacological drug manipulation creates causal mechanisms for selectively stimulating or blocking target neurotransmitter receptors known to modulate brain regions engaged in trust behavior. In this chapter, we review studies that used pharmacological agents to act as neuromodulators in the neural signaling pathway mechanisms underlying trust behavior. First, we describe the laboratory measurements of trust behavior, the underlying domain-general large-scale brain networks, and its related target neurotransmitter systems that probe trust behavior. Second, we review the psychopharmacological studies focusing first on studies that implemented the trust game and second on studies that applied trust ratings after cooperative exchange games. Overall, some preliminary evidence exists that neuromodulators such as opiates, monoamine neurotransmitters (e.g., serotonin, dopamine), and pharmacologic agents such as 3,4-Methyl-enedioxy-methamphetamine increase monoamine neurotransmitter activity and impact trust behavior via experimental paradigms that have face validity in laboratory measures of trust. Finally, we indicate shortcomings in the present psychopharmacological research approach and offer guidance for future interdisciplinary research on the neuropsychoeconomic underpinnings of trust –shedding light on trust impairment as a key feature of several neuropsychiatric disorders.

Keywords

neuromodulatorpropensity-based trustimpression-based trustexperience-based trustopiatesmonoamine neurotransmittersserotonindopaminenorepinephrine3,4-Methyl-enedioxy-methamphetamine
Type
Chapter
Information
The Neurobiology of Trust , pp. 338 - 368
Publisher: Cambridge University Press
Print publication year: 2021

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