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Case 2 - Primary Lateral Sclerosis (PLS)

from Disorders of the Anterior Horn Cell

Published online by Cambridge University Press:  29 November 2024

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

At about the age of 40, the patient noticed difficulty playing tennis. He could no longer hop easily from one leg to the other. After a game, he experienced pain in both legs. At age 43, he stopped taking part in competition, and five years later had to give up playing altogether. At that time, he sometimes missed the brake and accelerator pedals of his car. Walking became increasingly difficult. Sometimes he almost fell due to weakness of his left leg, and he had to use a walking stick. From the age of 50 onwards he used a wheelchair for outdoor transportation. At 52, he could only work part-time as his dexterity decreased. Urinary continence was not an issue, but when he felt the urge, he had to rush to the toilet. His family history was not informative.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 77 - 78
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

Hassan, A, Mittal, SO, Hu, WT, et al. Natural history of ‘pure’ primary lateral sclerosis. Neurology 2021;96(17):e2231e2238. doi: 10.1212/WNL.0000000000011771. Epub 2021 Feb 26. PMID: 33637635; PMCID: PMC8166429.CrossRefGoogle ScholarPubMed
Schito, P, Russo, T, Domi, T, et al. Clinical features and biomarkers to differentiate primary and amyotrophic lateral sclerosis in patients with an upper motor neuron syndrome. Neurology 2023;101(8):352356CrossRefGoogle ScholarPubMed
Shribman, S, Reid, E, Crosby, AH, Houlden, H, Warner, TT. Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches. Lancet Neurol 2019;18(12):11361146. doi: 10.1016/S1474-4422(19)30235-2. Epub 2019 Jul 31. PMID: 31377012.CrossRefGoogle ScholarPubMed
Turner, MR, Barohn, RJ, Corcia, P, et al.; Delegates of the 2nd International PLS Conference; Mitsumoto, H. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry 2020;91(4):373377. doi: 10.1136/jnnp-2019-322541. Epub 2020 Feb 6. PMID: 32029539; PMCID: PMC7147236.CrossRefGoogle ScholarPubMed

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