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Case 14 - Small-Fibre Neuropathy (SFN)

from Peripheral Neuropathies

Published online by Cambridge University Press:  29 November 2024

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

A 48-year-old man had complained about the painful soles of his feet for several months. This pain was present constantly but increased on touch and when walking. He was a marathon runner but could no longer train or walk properly because of the pain. He did not report weakness, sensory disturbances, discoloration of his feet, or swelling of his joints. Otherwise, he was healthy. He was not known to have diabetes mellitus or any other chronic disorder, such as sarcoidosis, which can cause a painful neuropathy. There were no cardiovascular or intestinal complaints, and no symptoms of autonomic dysfunction. Symptoms that could suggest malignancy were absent. He did not use any medication, had not been treated with any neurotoxic drug earlier, did not smoke, and drank only very limited amounts of alcohol. There was no family history of neurological disorders.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 110 - 113
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

Chan, ACY, Kumar, S, Tan, G, et al. Expanding the genetic causes of small-fiber neuropathy: SCN genes and beyond. Muscle Nerve 2023;67(4):259271. doi: 10.1002/mus.27752. Epub 2022 Nov 30. PMID: 36448457.CrossRefGoogle ScholarPubMed
Devigili, G, Cazzato, D, Lauria, G. Clinical diagnosis and management of small fiber neuropathy: an update on best practice. Expert Rev Neurother 2020;20(9):967980. doi: 10.1080/14737175.2020.1794825. Epub 2020 Jul 23. PMID: 32654574.CrossRefGoogle ScholarPubMed
Geerts, M, de Greef, BTA, Sopacua, M, et al. Intravenous immunoglobulin therapy in patients with painful idiopathic small fiber neuropathy. Neurology 2021;96(20):e2534e2545. doi: 10.1212/WNL.0000000000011919. Epub 2021 Mar 25. PMID: 33766992; PMCID: PMC8205474.CrossRefGoogle ScholarPubMed
Hoeijmakers, JGJ, Merkies, ISJ, Faber, CG. Small fiber neuropathies: expanding their etiologies. Curr Opin Neurol 2022;35(5):545552. doi: 10.1097/WCO.0000000000001103. Epub 2022 Aug 11. PMID: 35950732.Google ScholarPubMed
Sopacua, M, Hoeijmakers, JGJ, Merkies, ISJ, et al. Small-fiber neuropathy: expanding the clinical pain universe. J Peripher Nerv Syst 2019;24(1):1933. doi: 10.1111/jns.12298. Epub 2019 Jan 8. PMID: 30569495.CrossRefGoogle ScholarPubMed
Terkelsen, AJ, Karlsson, P, Lauria, G, et al. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017;16(11):934944. doi: 10.1016/S1474-4422(17)30329-0. Erratum in: Lancet Neurol. 2017 Dec;16(12):954. PMID: 29029847.CrossRefGoogle ScholarPubMed

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