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Chapter 26 - Autoimmune Disease

Published online by Cambridge University Press:  26 January 2024

By
Caroline S. Grange  and
Annika Smith
Edited by
David R. Gambling ,
M. Joanne Douglas  and
Grace Lim
David R. Gambling
Affiliation:
University of California, San Diego
M. Joanne Douglas
Affiliation:
University of British Columbia, Vancouver
Grace Lim
Affiliation:
University of Pittsburgh
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Summary

An autoimmune disease represents a pathological condition caused by an immune response directed against an antigen within the body of the host. The incidence and activity of autoimmune diseases are particularly high in young women and hence their occurrence in parturients is not uncommon. Autoimmune diseases often involve multiple systems and have a wide range of clinical manifestations and complications necessitating a multidisciplinary approach to management in the obstetric population, involving obstetricians, anesthesiologists, neonatologists, and rheumatologists. All affected organ systems should be evaluated and advice from appropriate medical specialties sought. The effect of autoimmune diseases and their treatment on pregnancy, and the effect of pregnancy on the disease itself varies between individual diseases. This chapter discusses the implications of the following autoimmune diseases in pregnancy: rheumatoid arthritis, systemic lupus erythematosus, polyarteritis nodosa, systemic sclerosis, antiphospholipid syndrome, and multiple sclerosis.

Keywords

rheumatoid arthritissystemic lupus erythematosuspolyarteritis nodosasystemic sclerosisantiphospholipid syndromemultiple sclerosis
Type
Chapter
Information
Obstetric Anesthesia and Uncommon Disorders , pp. 421 - 442
Publisher: Cambridge University Press
Print publication year: 2024

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