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8 - Fractionation with Two Modalities

Published online by Cambridge University Press:  05 October 2023

Archis Ghate
Archis Ghate
Affiliation:
University of Washington
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Summary

All previous chapters considered the optimal fractionation problem with a single radiation modality to administer dose. This chapter includes two competing modalities in a formulation of the fractionation problem using the LQ dose-response framework. The decision variables are thus the number of treatment sessions administered with each modality and the dose administered in each of these sessions via the corresponding modality. Two analytical methods for exact solution of this formulation are described. The effect of relative radiobiological powers and physical dose-deposition profiles of the two competing modalities on optimal treatment plans is explored via numerical experiments.

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Optimal Fractionation in Radiotherapy , pp. 96 - 121
Publisher: Cambridge University Press
Print publication year: 2023

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