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Chapter 14 - REM sleep behavior disorder

from Section 3 - Parasomnias usually associated with REM sleep

Published online by Cambridge University Press:  10 November 2010

By
Raffaele Manni  and
Michele Terzaghi
Edited by
Michael J. Thorpy  and
Giuseppe Plazzi
Michael J. Thorpy
Affiliation:
Montefiore Medical Center, Bronx, NY, USA
Giuseppe Plazzi
Affiliation:
Università di Bologna
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Summary

Rapid eye movement (REM) sleep behavior disorder (RBD) was first formally identified in 1986 by Schenck and Mahowald in five elderly subjects presenting similar motor behavioral patterns during REM sleep consisting of violent dream-enacting behaviors. The clinical manifestations of RBD are typically dream-related motor-behavioral manifestations that appear to be the enactment of a fight. Subclinical or preclinical RBD, status dissociatus and parasomnia overlap syndrome are the clinical-pathophysiological subtypes of RBD, according to ICSD-2. The literature contains anecdotal reports of co-existing RBD and narcolepsy in both adults and children, in some cases with the RBD episodes as the presenting symptoms. The parasomnia and non-parasomnia disorders are taken into account in the differential diagnosis of RBD. In humans, RBD has been associated with several etiologies and abnormalities. Anecdotal reports and uncontrolled, retrospective studies of small patient series suggest that levodopa and pramipexole (D3 agonist) reduce RBD manifestations.

Keywords

anti-depressant medicationsbenzodiazepinesNREM parasomniastriazolamslow-wave sleepsleepwalkingschizoaffective patientssleep-related eating disorder
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Chapter
Information
The Parasomnias and Other Sleep-Related Movement Disorders , pp. 131 - 141
Publisher: Cambridge University Press
Print publication year: 2010

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