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Chapter 9 - Hereditary and Acquired Tubulointerstitial Diseases

from Section 3 - Tubulointerstitial Diseases

Published online by Cambridge University Press:  10 August 2023

By
Amélie Dendooven  and
Elena Levtchenko
Edited by
Helen Liapis
Helen Liapis
Affiliation:
Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
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Summary

Many entities affect specifically the tubulointerstitium, most often sparing the glomeruli and vessels, but exact subclassification is difficult because the histologic findings may have overlapping features. Frequently biopsies are performed shortly after symptoms manifest (in the acute phase). There is controversy in the terminology of chronic lesions; for example the term chronic pyelonephritis, particularly in the pediatric population, has fallen out of favor, replaced by other terms such as reflux nephropathy. However, careful examination and clinicopathologic correlation helps to pinpoint the cause and guide appropriate patient management. In this chapter, the focus is on the histopathology of acquired and hereditary tubulointerstitial diseases in native kidneys.

Keywords

Tubulointerstitial nephritisacute interstitial nephritispyelonephritissarcoidosistubulointerstitial nephritis with uveitisSjögren syndromekaryomegalic interstitial nephritisrenal tubular dysgenesisBartter syndrome
Type
Chapter
Information
Pediatric Nephropathology & Childhood Kidney Tumors , pp. 181 - 196
Publisher: Cambridge University Press
Print publication year: 2023

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