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14 - Status Epilepticus

from Section 3 - Neurological Emergencies

Published online by Cambridge University Press:  02 November 2023

Kaushal Shah
Affiliation:
Weill Cornell Medical Center, New York
Jarone Lee
Affiliation:
Massachusetts General Hospital, Boston
Clark G. Owyang
Affiliation:
Weill Cornell Medical Center, New York
Benjamin Christian Renne
Affiliation:
Massachusetts General Hospital, Boston
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Summary

  • In generalized convulsive status epilepticus (GCSE), a seizure lasts longer than 5 minutes or two seizures occur without an interval return to baseline.

  • The most common error in managing status epilepticus is not administering enough benzodiazepine. If the patient is refractory to benzodiazepines, there are multiple appropriate agents for second-line treatment (e.g., levetiracetam, valproate, fosphenytoin). A timely and early intubation may be the safest option and provide the best outcome for the patient.

  • Nonconvulsive status epilepticus (NCSE) presents without muscle involvement, and may be suspected clinically, but needs electroencephalography (EEG) to make the diagnosis.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2023

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References

Kapur, J, Elm, J, Chamberlain, J, et al. Randomized trial of three anticonvulsant medications for status epilepticus. N Engl J Med 2019;381(22):21032113. https://doi.org/10.1056/NEJMoa1905795CrossRefGoogle ScholarPubMed
Silbergleit, R, Durkalski, V, Lowenstein, D, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med 2012;366:591600.CrossRefGoogle ScholarPubMed
Treiman, DM, Meyers, PD, Walton, NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 1998;339:792798.CrossRefGoogle ScholarPubMed

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