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Chapter 1 - Clinical Epidemiology

Published online by Cambridge University Press:  04 April 2024

By
James B. Kirkbride  and
Annie Jeffery
Edited by
David Kingdon ,
Paul Rowlands  and
George Stein
David Kingdon
Affiliation:
University of Southampton
Paul Rowlands
Affiliation:
Derbyshire Healthcare NHS foundation Trust
George Stein
Affiliation:
Emeritus of the Princess Royal University Hospital
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Summary

This chapter gives an introduction to key concepts in epidemiology for the clinician, student, trainee or early career researcher interested in psychiatry and mental health. Following a brief introduction to the history of epidemiology, we provide a comprehensive, yet accessible introduction to key epidemiological concepts and how these apply to psychiatry and mental health. We introduce the major observational (cohort, case-control, cross-sectional, ecological) and experimental (randomised controlled trial) designs used in epidemiology, their strengths and limitations and specific issues for their use in psychiatry. We also cover measures of disease frequency (incidence, prevalence), measures of effect (risk, rate and odds ratios) and measures of impact (population attributable risk). Our chapter then provides a comprehensive introduction to traditional and contemporary approaches to understanding the critical issue of causation, illustrated via the use of causal diagrams known as Directed Acyclic Graphs. Throughout, we use accessible examples from published research and hypothetical worked examples to consolidate the reader’s knowledge about key methods in psychiatric epidemiology.

Keywords

psychiatric epidemiologyclinical epidemiologymental healthcausal inferencecohort studiescase-control studiesrandomised controlled trialsbiasconfounding
Type
Chapter
Information
Seminars in General Adult Psychiatry , pp. 6 - 29
Publisher: Cambridge University Press
Print publication year: 2024

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