Book contents
- Frontmatter
- Contents
- Contents (contents of Volume II)
- Preface
- Contributors (contributors of Volume I)
- Contributors (contributors of Volume II)
- Neural repair and rehabilitation: an introduction
- Section A Neural plasticity
- Section A1 Cellular and molecular mechanisms of neural plasticity
- 1 Anatomical and biochemical plasticity of neurons: regenerative growth of axons, sprouting, pruning, and denervation supersensitivity
- 2 Learning and memory: basic principles and model systems
- 3 Short-term plasticity: facilitation and post-tetanic potentiation
- 4 Long-term potentiation and long-term depression
- 5 Cellular and molecular mechanisms of associative and nonassociative learning
- Section A2 Functional plasticity in CNS system
- Section A3 Plasticity after injury to the CNS
- Section B1 Neural repair
- Section B2 Determinants of regeneration in the injured nervous system
- Section B3 Promotion of regeneration in the injured nervous system
- Section B4 Translational research: application to human neural injury
- Index
4 - Long-term potentiation and long-term depression
from Section A1 - Cellular and molecular mechanisms of neural plasticity
Published online by Cambridge University Press: 05 March 2012
Book contents
- Frontmatter
- Contents
- Contents (contents of Volume II)
- Preface
- Contributors (contributors of Volume I)
- Contributors (contributors of Volume II)
- Neural repair and rehabilitation: an introduction
- Section A Neural plasticity
- Section A1 Cellular and molecular mechanisms of neural plasticity
- 1 Anatomical and biochemical plasticity of neurons: regenerative growth of axons, sprouting, pruning, and denervation supersensitivity
- 2 Learning and memory: basic principles and model systems
- 3 Short-term plasticity: facilitation and post-tetanic potentiation
- 4 Long-term potentiation and long-term depression
- 5 Cellular and molecular mechanisms of associative and nonassociative learning
- Section A2 Functional plasticity in CNS system
- Section A3 Plasticity after injury to the CNS
- Section B1 Neural repair
- Section B2 Determinants of regeneration in the injured nervous system
- Section B3 Promotion of regeneration in the injured nervous system
- Section B4 Translational research: application to human neural injury
- Index
Summary
This chapter concentrates on the basic mechanisms that are thought to underlie induction and expression of long-term plasticity (LTP). LTP has been demonstrated at all of the major synapses in the hippocampus. Activity-dependent LTP is a commonly observed feature of the neocortex and does not differ from the hippocampus in its induction or expression mechanisms. The induction and/or the magnitude of LTP and long-term depression (LTD) can be affected by prior activity that in itself does not produce observable changes in synaptic efficacy. Thus there is some plastic change of a different, or meta, form that influences traditional synaptic plasticity. N-methyl-D-aspartate receptors (NMDAR)-mediated synaptic transmission can undergo potentiation and depression, and given the critical role for NMDARs in LTP and LTD induction it is apparent that any change in NMDAR synaptic transmission brought about by a priming stimulus could have dramatic consequences for induction of LTP and LTD.
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- Textbook of Neural Repair and Rehabilitation , pp. 60 - 78Publisher: Cambridge University PressPrint publication year: 2006
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