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Chapter 21 - A Dynamical Systems Perspective on Thalamic Circuit Function

from Section 9: - Computation

Published online by Cambridge University Press:  12 August 2022

By
Qinglong L. Gu  and
John D. Murray
Edited by
Michael M. Halassa
Michael M. Halassa
Affiliation:
Massachusetts Institute of Technology
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Summary

This chapter applies a perspective from biophysically grounded computational modeling to explore how the intrinsic properties of thalamic microcircuits support the computational roles that the thalamus plays in perceptual and cognitive functions. A key focus is on the modeling of neurophysiological activity in the thalamus as nonlinear dynamical systems. Dynamical modeling can give insight into thalamic function across levels of analysis, including cellular channel properties, synaptic plasticity, and anatomical connectivity. This chapter reviews how the interplay between cellular and circuit mechanisms supports thalamic contributions to neural oscillations, regulation of brain state, top-down attentional control of sensory processing, and other cognitive functions. Understanding circuit function through biophysically grounded computational modeling and dynamical systems perspectives can also provide insight into how cellular and synaptic alterations caused by pharmacology or disease can impair thalamic function.

Keywords

computational modeldynamical systemsburst firingshort-term plasticityoscillationsgainattention
Type
Chapter
Information
The Thalamus , pp. 401 - 415
Publisher: Cambridge University Press
Print publication year: 2022

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