This book integrates philosophy of science, data acquisition methods, and statistical modeling techniques to present readers with a forward-thinking perspective on clinical science. It reviews modern research practices in clinical psychology that support the goals of psychological science, study designs that promote good research, and quantitative methods that can test specific scientific questions. It covers new themes in research including intensive longitudinal designs, neurobiology, developmental psychopathology, and advanced computational methods such as machine learning. Core chapters examine significant statistical topics, for example missing data, causality, meta-analysis, latent variable analysis, and dyadic data analysis. A balanced overview of observational and experimental designs is also supplied, including preclinical research and intervention science. This is a foundational resource that supports the methodological training of the current and future generations of clinical psychological scientists.

'The editors have produced an indispensable tome. For the first time, the various methods and approaches used by clinical psychology researchers have been brought together. This book represents a watershed moment in the development of clinical psychology as a scientific discipline and belongs on the bookshelves of all clinical psychologists.'

Robert F. Krueger - Distinguished McKnight University Professor, University of Minnesota

'This handbook provides a much-needed primer on a range of methods important for clinical science. It would be an excellent addition to a graduate introductory course on methods in clinical science or a very useful resource for more advanced researchers wanting to learn about new approaches and methods in the field.'

Deanna M. Barch - Chair and Professor of Psychological and Brain Sciences, Washington University, St Louis

'Assembled by two highly respected clinical scientists, this handbook is current, comprehensive, and sophisticated. Researchers across a wide spectrum of experience will find this volume invaluable to their work. Written by leading experts, the chapters discuss methodological and quantitative approaches to address clinical psychology’s most pressing questions.'

Josh Miller - Professor and Director of Clinical Training, University of Georgia

'This comprehensive treatment of the cutting-edge methods and procedures used in the rapidly evolving field of clinical research should be a go-to resource for anyone interested in the state-of-the-art in the discipline of clinical psychology. Topics as diverse as latent variable models, molecular genetics, functional imaging, and the replication crisis all receive clear and detailed consideration.'

Leslie C. Morey - George T. and Gladys H. Abell Professor, Texas A&M University