Book contents
- Uncommon Causes of Stroke
- Uncommon Causes of Stroke
- Copyright page
- Contents
- List of Contributors
- Preface
- PART I: INFECTIOUS AND INFLAMMATORY CONDITIONS
- PART II: HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
- 16 PULMONARY ARTERIOVENOUS MALFORMATIONS
- 17 HEREDITARY HEMORRHAGIC TELANGIECTASIA (OSLER–WEBER–RENDU DISEASE)
- 18 CEREBRAL AUTOSOMAL DOMINANT ARTERIOPATHY WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY (CADASIL)
- 19 CEREBROVASCULAR COMPLICATIONS OF FABRY’S DISEASE
- 20 MARFAN’S SYNDROME
- 21 PSEUDOXANTHOMA ELASTICUM
- 22 EHLERS-DANLOS SYNDROME
- 23 PROGERIA
- 24 MELAS AND OTHER MITOCHONDRIAL DISORDERS
- 25 STURGE-WEBER SYNDROME
- 26 VON HIPPEL-LINDAU DISEASE
- 27 ANEURYSMS
- 28 ARTERIOVENOUS MALFORMATIONS OF THE BRAIN
- 29 CEREBRAL CAVERNOUS MALFORMATIONS AND DEVELOPMENTAL VENOUS ANOMALIES
- 30 CEREBROVASCULAR MANIFESTATIONS OF NEUROFIBROMATOSIS
- 31 MENKES DISEASE (KINKY HAIR DISEASE)
- 32 WYBURN-MASON SYNDROME
- PART III: VASCULAR CONDITIONS OF THE EYES, EARS, AND BRAIN
- PART IV: DISORDERS INVOLVING ABNORMAL COAGULATION
- PART V: SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
- PART VI: NONINFLAMMATORY DISORDERS OF THE ARTERIAL WALL
- PART VII: VENOUS OCCLUSIVE CONDITIONS
- PART VIII: VASOSPASTIC CONDITIONS AND OTHER MISCELLANEOUS VASCULOPATHIES
- PART IX: OTHER MISCELLANEOUS CONDITIONS
- Index
30 - CEREBROVASCULAR MANIFESTATIONS OF NEUROFIBROMATOSIS
from PART II: - HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
Published online by Cambridge University Press: 06 January 2010
Book contents
- Uncommon Causes of Stroke
- Uncommon Causes of Stroke
- Copyright page
- Contents
- List of Contributors
- Preface
- PART I: INFECTIOUS AND INFLAMMATORY CONDITIONS
- PART II: HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
- 16 PULMONARY ARTERIOVENOUS MALFORMATIONS
- 17 HEREDITARY HEMORRHAGIC TELANGIECTASIA (OSLER–WEBER–RENDU DISEASE)
- 18 CEREBRAL AUTOSOMAL DOMINANT ARTERIOPATHY WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY (CADASIL)
- 19 CEREBROVASCULAR COMPLICATIONS OF FABRY’S DISEASE
- 20 MARFAN’S SYNDROME
- 21 PSEUDOXANTHOMA ELASTICUM
- 22 EHLERS-DANLOS SYNDROME
- 23 PROGERIA
- 24 MELAS AND OTHER MITOCHONDRIAL DISORDERS
- 25 STURGE-WEBER SYNDROME
- 26 VON HIPPEL-LINDAU DISEASE
- 27 ANEURYSMS
- 28 ARTERIOVENOUS MALFORMATIONS OF THE BRAIN
- 29 CEREBRAL CAVERNOUS MALFORMATIONS AND DEVELOPMENTAL VENOUS ANOMALIES
- 30 CEREBROVASCULAR MANIFESTATIONS OF NEUROFIBROMATOSIS
- 31 MENKES DISEASE (KINKY HAIR DISEASE)
- 32 WYBURN-MASON SYNDROME
- PART III: VASCULAR CONDITIONS OF THE EYES, EARS, AND BRAIN
- PART IV: DISORDERS INVOLVING ABNORMAL COAGULATION
- PART V: SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
- PART VI: NONINFLAMMATORY DISORDERS OF THE ARTERIAL WALL
- PART VII: VENOUS OCCLUSIVE CONDITIONS
- PART VIII: VASOSPASTIC CONDITIONS AND OTHER MISCELLANEOUS VASCULOPATHIES
- PART IX: OTHER MISCELLANEOUS CONDITIONS
- Index
Summary
Neurofibromatosis (NF) is an autosomal dominant disorder encompassing several distinct genetic defects with overlapping clinical features. This chapter focuses on the main genetic, clinical, pathological, and radiological features of neurofibromatosis type 1 (NF1). The cerebrovascular manifestations of NF1 include cerebral ischemia, intracranial hematoma, and subarachnoidal hemorrhage. Recurrent strokes can occur in the same or in different territories. Every large or medium-sized artery can be affected, and some patients have multiple stenoses of intracranial vessels combined with stenoses or occlusion of extracranial vessel. Hemispheric territorial infarction is a common stroke manifestation. Ocular involvement may present with retinal ischemia or global ocular ischemia. Angiography, time-of-flight magnetic resonance angiography (TOF-MRA) and Color duplex and spectral Doppler ultrasonography are useful diagnostic modalities for revealing the vascular complications of NF1. Neurosurgical revascularization in patients with moyamoya syndrome has been shown to reduce the risk of first-ever and recurrent stroke and transient ischemic attack (TIA).
Keywords
- Type
- Chapter
- Information
- Uncommon Causes of Stroke , pp. 221 - 224Publisher: Cambridge University PressPrint publication year: 2008