Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-13T12:49:55.189Z Has data issue: false hasContentIssue false

46 - RHEUMATOID ARTHRITIS AND CEREBROVASCULAR DISEASE

from PART V: - SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM

Published online by Cambridge University Press:  06 January 2010

Louis R. Caplan
Affiliation:
Beth Israel Deaconess Medical Center, Boston
Julien Bogousslavsky
Affiliation:
Valmont Clinique, Glion, Switzerland
Get access

Summary

Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by an inflammatory, symmetric polyarthritis. The mechanisms by which RA patients are predisposed to stroke are varied. The most common of these causes is atherosclerotic disease, which seems to be accelerated by the underlying RA. The role of systemic inflammation in mediating atherosclerotic disease is becoming clear and may be the underlying link between RA and vascular events. Systemic vasculitis in RA involves the vasa nervorum of the peripheral nervous system. Meningeal and brain biopsy remains the gold standard in confirming a diagnosis of vasculitis in RA patients. Although there is a theoretical risk of mechanical injury to the vertebral artery due to cervical arthritis and atlantoaxial subluxation in RA, this most often results in cervical myelopathy. Stroke due to vertebral dissection has been reported in RA, but the vertebral artery occlusion was sometimes associated with only minimal atlantoaxial subluxation.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×