The purpose of this article is to correct and expand our understanding of an interrelated group of socially prominent families from Roman Sparta and Epidaurus. Part I publishes an inscription from Sparta, dating to about 240, which attests new members of the Spartan families of the Claudii and the Pomponii: respectively Claudia Tyrannis, a great-granddaughter of the senator Tib. Claudius Brasidas, and C. Pomponius Aristeas qui et Pericles, her husband. At the same time, a revised account is offered of the Claudii and of a further four Spartan families to which they were related: the Memmii, the Voluseni, the Aelii, and the Pompeii. Part II re-examines the evidence for the Epidaurian family of the Statilii. Apart from the new inscription, more recent work on the epigraphic corpora from Sparta and the Asclepieum, the possibility of reinterpreting the older material, and the need to take hitherto neglected documents into account, together seem to justify a fresh treatment of these families. The resulting study, as well as providing up-to-date family histories, includes many corrections on detailed points of local epigraphy, chronology, and prosopography.