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Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma

Published online by Cambridge University Press:  09 March 2007

A. J. Day  and
G. Williamson
A. J. Day
Affiliation:
Diet, Health and Consumer Sciences Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
G. Williamson*
Affiliation:
Diet, Health and Consumer Sciences Division, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
*
*Corresponding author: Dr G. Williamson, fax +44 (0) 1603 507723, emailgary.williamson@bbsrc.ac.uk
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Abstract

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Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue S1 , August 2001 , pp. S105 - S110
Copyright
Copyright © The Nutrition Society 2001

References

Aziz, AA, Edwards, CA, Lean, MEJ & Crozier, A (1998) Absorption and excretion of conjugated flavonols, including quercetin 4′-O-β-glucoside and isorhamnetin 4′-O-β-glucoside, by human volunteers. Free Radical Research 29, 257–269.CrossRefGoogle Scholar
Baba, S, Furuta, T, Fujioka, M & Goromaru, T (1983) Studies on drug-metabolism by use of isotopes XXVII: urinary metabolites of rutin in rats and the role of intestinal microflora in the metabolism of rutin. Journal of Pharmaceutical Sciences 72, 1155–1158.CrossRefGoogle Scholar
Baba, S, Furuta, T, Horie, M & Nakagawa, H (1981) Studies on drug metabolism by use of isotopes XXVI: determination of urinary metabolites of rutin in humans. Journal of Pharmacological Science 70, 780–782.Google ScholarPubMed
Bourne, LC & Rice-Evans, CA (1998) Urinary detection of hydroxycinnamates and flavonoids in humans after high dietary intake of fruit. Free Radical Research 28, 429–438.CrossRefGoogle ScholarPubMed
Bourne, LC & Rice-Evans, CA (1999) Detecting and measuring bioavailability of phenolics and flavonoids in humans: pharmacokinetics of urinary excretion of dietary ferulic acid. Methods in Enzymology 299, 91–106.CrossRefGoogle ScholarPubMed
Crespy, V, Morand, C, Besson, C, Manach, C, Démigné, C & Rémésy, C (1999b) Intestinal metabolism of quercetin 3-O-glucose in rats. SFRR Europe Winter Meeting: Bioflavonoids and polyphenols in health and disease, Dinard, France, P002.Google Scholar
Crespy, V, Morand, C, Manach, C, Besson, C, Démigné, C & Rémésy, C (1999a) Part of quercetin absorbed in the small intestine is conjugated and further secreted in the lumen. American Journal of Physiology 277, G120–G126.Google ScholarPubMed
Day, AJ, Cañada, FJ, Díaz, JC, Kroon, PA, Mclauchlan, R, Faulds, CB, Plumb, GW, Morgan, MRA & Williamson, G (2000) Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Letters 468, 166–170.CrossRefGoogle ScholarPubMed
Day, AJ, DuPont, MS, Ridley, S, Rhodes, M, Rhodes, MJC, Morgan, MRA & Williamson, G (1998) Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity. FEBS Letters 436, 71–76.CrossRefGoogle ScholarPubMed
deVries, JHM, Hollman, PCH, Meyboom, S, Buysman, MNCP, Zock, PL, van Staveren, WA & Katan, MB (1998) Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake. American Journal of Clinical Nutrition 68, 60–65.CrossRefGoogle Scholar
Gee, JM, DuPont, MS, Rhodes, MJC & Johnson, IT (1998) Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radical Biology and Medicine 25, 19–25.CrossRefGoogle ScholarPubMed
Gee, JM, DuPont, MS, Day, AJ, Plumb, GW, Williamson, G & Johnson, I (2000) Uptake of quercetin glycosides involves deglycosylation and interaction with the sodium-dependent glucose transport pathway in rat small intestine. Journal of Nutrition 130, 2765–2771.CrossRefGoogle Scholar
Hirayama, BA, Lostao, MP, Panayotova-Heiermann, M, Loo, DD, Turk, E & Wright, EM (1996) Kinetic and specificity differences between rat, human, and rabbit Na+- glucose cotransporters (SGLT-1). American Journal of Physiology 270, G919-G926.Google ScholarPubMed
Hollman, PCH, Buysman, MNCP, van Gameren, Y, Cnossen, EPJ, deVries, JHM & Katan, MB (1999) The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radical Research 31, 569–573.CrossRefGoogle Scholar
Hollman, PCH, van Trijp, JMP & Buysman, MNCP (1996) Fluorescence detection of flavonols in HPLC by postcolumn chelation with aluminium. Analytical Chemistry 68, 3511–3515.CrossRefGoogle Scholar
Hollman, PCH, van Trijp, JMP, Buysman, MNCP, Gaag, MS, Menglers, MJB, deVries, JHM & Katan, MB (1997) Relative bioavailablity of the antioxidant quercetin from various foods in man. FEBS Letters 418, 152–156.CrossRefGoogle Scholar
Ioku, K, Pongpiriyadacha, Y, Konishi, Y, Takei, Y, Nakatani, N & Terao, J (1998) β-Glucosidase activity in the rat small intestine towards quercetin monoglucosides. Bioscience Biotechnology Biochemistry 62, 1428–1431.CrossRefGoogle Scholar
Janseen, PLTM, Mensink, RP, Cox, FJJ, Harryvan, JL, Hovenier, R, Hollman, PCH & Katan, MB (1998) Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. American Journal of Clinical Nutrition 67, 255–262.CrossRefGoogle Scholar
Lambert, N, Kroon, PA, Faulds, CB, Plumb, GW, McLauchlan, WR, Day, AJ & Williamson, G (1999) Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides. Biochimica et Biophysica Acta – Protein Structure and Molecular Enzymology 1435, 110–116.CrossRefGoogle ScholarPubMed
Lostao, MP, Hirayama, BA, Loo, DDF & Wright, EM (1994) Phenylglucosides and the Na+/glucose cotransporter (SGLT1) – analysis of interactions. Journal of Membrane Biology 142, 161–170.CrossRefGoogle ScholarPubMed
Mabry, TJ, Markham, KP & Thomas, MB (1970) The Systematic Identification of Flavonoids. New York: Springer-Verlag.CrossRefGoogle Scholar
Manach, C, Morand, C, Crespy, V, Démigné, C, Texier, O, Regerat, F & Rémésy, C (1998) Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Letters 426, 331–336.CrossRefGoogle ScholarPubMed
Manach, C, Morand, C, Démigné, C, Texier, O, Régérat, F & Rémésy, C (1997) Bioavailability of rutin and quercetin in rats. FEBS Letters 409, 12–16.CrossRefGoogle ScholarPubMed
Mauri, PL, Iemoli, L, Gardana, C, Riso, P, Simonetti, P, Porrini, M & Pietta, PG (1999) Liquid chromatography/electrospray ionization mass spectrometeric characterization of flavonol glycosides in tomato extracts and human plasma Rapid Communication in Mass Spectrotrometry 13, 924–931.3.0.CO;2-G>CrossRefGoogle Scholar
Mizuma, T & Awazu, S (1998) Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats. Biochimica et Biophysica Acta – General Subjects 1425, 398–404.CrossRefGoogle ScholarPubMed
Morand, C, Crespy, V, Manach, C, Besson, C, Demigne, C & Rémésy, C (1998) Plasma metabolites of quercetin and their antioxidant properties. American Journal of Physiology 44, R212-R219.Google Scholar
Morand, C, Manach, C, Crespy, V & Remesy, C (2000) Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radical Research 33, 667–672.CrossRefGoogle Scholar
Paganga, G & Rice-Evans, C (1997) The identification of flavonoids as glycosides in human plasma. FEBS Letters 401, 78–82.CrossRefGoogle ScholarPubMed
Panayotova-Heiermann, M, Loo, DD, Kong, CT, Lever, JE & Wright, EM (1996) Sugar binding to Na+/glucose cotransporters is determined by the carboxyl-terminal half of the protein. Journal of Biological Chemistry 271, 10029–10034.CrossRefGoogle Scholar
Park, YK & Lee, CY (1996) Identification of isorhamnetin 4′-glucoside in onions. Journal of Agricultural and Food Chemistry 44, 34–36.CrossRefGoogle Scholar
Price, KR, Prosser, T, Richetin, AMF & Rhodes, MJC (1999) A comparison of the flavonol content and composition in dessert, cooking and cider-making apples; distribution within the fruit and effect of juicing. Food Chemistry 66, 489–494.CrossRefGoogle Scholar
Rivera-Sagredo, A, Cañada, FJ, Nieto, O, Jimenez-Barbero, J & Martín-Lomas, M (1992) Substrate-specificity of small-intestinal lactase – assessment of the role of the substrate hydroxyl-groups. European Journal of Biochemistry 209, 415–422.CrossRefGoogle ScholarPubMed
Saija, A, Scalese, M, Lanza, M, Marzullo, D, Bonina, F & Castelli, F (1995) Flavonoids as antioxidant agents – importance of their interaction with biomembranes. Free Radical Biology and Medicine 19, 481–486.CrossRefGoogle ScholarPubMed
Spencer, JPE, Chowrimootoo, G, Choudhury, R, Debnam, ES, Srai, SK & RiceEvans, C (1999) The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Letters 458, 224–230.CrossRefGoogle ScholarPubMed
Williamson, G, Plumb, GW, Uda, Y, Price, KR & Rhodes, MJC (1996) Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis 17, 2385–2387.CrossRefGoogle ScholarPubMed
Young, JF, Nielsen, SE, Haraldsdottir, J, Daneshvar, B, Lauridsen, ST, Knuthsen, P, Crozier, A, Sandstrom, B & Dragsted, LO (1999) Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidant status. American Journal of Clinical Nutrition 69, 87–94.CrossRefGoogle Scholar