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Kinetics of amino acid and glucose absorption following pancreatic diversion in the pig

Published online by Cambridge University Press:  09 March 2007

A. Rérat ,
R. Calmes ,
T. Corring  and
P. Vaissade
A. Rérat
Affiliation:
Departement NASA, CRJ-INRA, Domaine de Vilvert, Jouy-en-Josas 78352, France
R. Calmes
Affiliation:
Departement NASA, CRJ-INRA, Domaine de Vilvert, Jouy-en-Josas 78352, France
T. Corring
Affiliation:
UEPSD, CRJ-INRA, Dornaine de Vilvert, Jouy-en-Josas 78352, France
P. Vaissade
Affiliation:
UEPSD, CRJ-INRA, Dornaine de Vilvert, Jouy-en-Josas 78352, France
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Abstract

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An experiment was conducted in the pig to determine the consequences of deprivation of exocrine pancreatic secretion on the composition and quantity of nutrients absorbed after intake of a balanced diet. Five growing pigs (53·8 kg body weight) were fitted with permanent catheters in the portal vein and the carotid artery and with an electromagnetic flow probe around the portal vein to measure the exchanges between the blood and the intestinal lumen. They were also fitted with a permanent catheter in the duct of Wirsung to educe the exocrine pancreatic secretion and another one in the duodenum in order to reintroduce it. In each animal, glucose, amino-N and amino acid absorption as well as insulin and glucagon production were measured over a period of 10 h after the meal (semi-purified diet based on purified starch and containing 180 g fish meal/kg, DM content of the meal 731 g), either in the presence of pancreatic juice (group C : immediate reintroduction), or in the absence of pancreatic juice (group D: deprivation). The deprivation of pancreatic juice provoked a marked depression in the absorption of glucose (D 67·9 (SEM 27·9) g/10 h, C 437·7 (SEM 39·5) g/10 h, P < 0·00l), and of amino-N (D 7·55 (SEM 0·54) g/10 h, C 15·80 (SEM 0·79) g/10 h, P < 0·001). The composition of the mixture of amino acids in the portal blood was only slightly modified: only the levels of histidine (P < 0·05) and of valine (P < 0·06, NS) decreased in the absence of pancreatic juice. Insulin production was much lower (by 64%, P < 0·05) in the absence of pancreatic juice whereas that of glucagon was not affected.

Keywords

Pancreatic diversionGlucose absorptionAmino acid absorptionInsulin secretion
Type
Nutrient absorption kinetics in pigs
Information
British Journal of Nutrition , Volume 75 , Issue 2 , February 1996 , pp. 175 - 193
Copyright
Copyright © The Nutrition Society 1996

References

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