Strikingly innovative developments in brain science during the past two decades, reflecting advances in a dozen different biological disciplines (such as biochemistry, biophysics, endocrinology, neuropsychology, genetics, and human development) have created a new psychobiology that thus far appears to have had only slight impact upon mainstream political science theory and research. This field analysis examines the implications of psychobiology for the study and practice of politics, from the perspective of the founding father of political behaviouralism. The article discusses the psychobiology of mind in terms of human consciousness and memory and then examines the epigenetic and recursive relationships between brain structure and political perception; between brain lateralization and dynamics, and political thinking and decision-making; and between brain development and political equality, with particular regard to sex, age, health, race, and intelligence.