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Congenital ductus arteriosus aneurysm in association with MYH11 mutation: a case report

Part of: Basic Science

Published online by Cambridge University Press:  09 January 2020

Mohanageetha Ardhanari  and
Sethuraman Swaminathan Open the ORCID record for Sethuraman Swaminathan [Opens in a new window]
Mohanageetha Ardhanari
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, Jackson Memorial Hospital, University of Miami, Miller School of Medicine, Miami, FL, USA
Sethuraman Swaminathan*
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, Jackson Memorial Hospital, University of Miami, Miller School of Medicine, Miami, FL, USA
*
Author for correspondence: S. Swaminathan, MD, Division of Pediatric Cardiology, Department of Pediatrics, Jackson Memorial Hospital, Miller School of Medicine, University of Miami, 1611 NW 12th Ave, North Wing Rm 109, Miami, FL33136, USA. Tel: +1 305 585 6683; Fax: +1 305 324 6012; E-mail: sswami@miami.edu
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Abstract

Congenital ductus arteriosus aneurysms develop in the third trimester of fetal life, possibly due to abnormal intimal cushion formation or elastin expression in the ductal wall. It is often diagnosed in infants before 2 months of age. Most have a benign course and resolve spontaneously. However, life-threatening complications have been reported. We report a case of large ductal aneurysm diagnosed incidentally in a neonate, in whom there was a novel mutation in the smooth muscle myosin protein gene—MYH11.

Keywords

Ductus arteriosus aneurysmpatent ductus arteriosusconnective tissue disorder
Type
Brief Report
Information
Cardiology in the Young , Volume 30 , Issue 1 , January 2020 , pp. 123 - 125
Copyright
© Cambridge University Press 2020

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