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Everolimus-induced near-resolution of giant cardiac rhabdomyomas and large renal angiomyolipoma in a newborn with tuberous sclerosis complex

Published online by Cambridge University Press:  08 April 2016

Massimo Colaneri ,
Andrea Quarti  and
Marco Pozzi
Massimo Colaneri*
Affiliation:
Department of Paediatric and Congenital Cardiac Surgery and Cardiology, Ospedali Riuniti, Ancona, Italy
Andrea Quarti
Affiliation:
Department of Paediatric and Congenital Cardiac Surgery and Cardiology, Ospedali Riuniti, Ancona, Italy
Marco Pozzi
Affiliation:
Department of Paediatric and Congenital Cardiac Surgery and Cardiology, Ospedali Riuniti, Ancona, Italy
*
Correspondence to: M. Colaneri, MD, Department of Paediatric and Congenital Cardiac Surgery and Cardiology, Ospedali Riuniti, Via Conca 71, 60126 Ancona, Italy. Tel: +39 71 596 5477; Fax: +39 71 596 5360; E-mail: massimo.colaneri@icloud.com
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Abstract

We report a case of a newborn, affected by tuberous sclerosis complex, with a prenatally diagnosed giant cardiac rhabdomyoma associated with a large renal angiomyolipoma presenting as a duct-depending lesion not treatable by surgery. After receiving everolimus, a mammalian target of rapamycin inhibitor, we observed a rapid, significant, and durable reduction of both lesions without remarkable side effects.

Keywords

Cardiac rhabdomyomaangiomyolipomaeverolimustuberous sclerosis complex
Type
Brief Reports
Information
Cardiology in the Young , Volume 26 , Issue 5 , June 2016 , pp. 1025 - 1028
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Copyright
© Cambridge University Press 2016 

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