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Medical and surgical perspectives of cardiac hypertrophy in Costello syndrome

Published online by Cambridge University Press:  14 October 2009

David Kalfa ,
Alain Fraisse  and
Bernard Kreitmann
David Kalfa*
Affiliation:
Department of Thoracic and Cardio-Vascular Surgery, La Timone Children’s Hospital, Marseille, France
Alain Fraisse
Affiliation:
Department of Paediatric Cardiology, La Timone Children’s Hospital, Marseille, France
Bernard Kreitmann
Affiliation:
Department of Thoracic and Cardio-Vascular Surgery, La Timone Children’s Hospital, Marseille, France
*
Correspondence to: David Kalfa, Service de Chirurgie Thoracique et Cardio-vasculaire, Hôpital La Timone Enfants, Centre Hospitalier Universitaire Marseille, 264 rue Saint-Pierre, 13385 Marseille, France. Tel: +33 6 17 09 14 88; Fax: +33 491 384 576; E-mail: davidkalfa@gmail.com
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Abstract

We describe our experience with 2 patients having Costello syndrome, aged 11 and 36 months, who suffered systolic anterior motion of the aortic leaflet of the mitral valve and obstructive cardiac hypertrophy requiring surgery, comparing their cardiac characteristics to those described previously. We conclude that the heterogeneous nature of the cardiac hypertrophy in this syndrome can be considered and managed as the sum of a diffuse hypertrophy accessible to beta-blockade, and an asymmetric hypertrophy accessible to surgical myomectomy.

Keywords

Beta-blockershypertrophic cardiomyopathygenetic syndromesubaortic stenosissupraventricular tachycardiasurgical myomectomy
Type
Brief Reports
Information
Cardiology in the Young , Volume 19 , Issue 6 , December 2009 , pp. 644 - 647
Copyright
Copyright © Cambridge University Press 2009

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References

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