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Pre-operative neutrophil–lymphocyte ratio predicts low cardiac output in children after cardiac surgery

Published online by Cambridge University Press:  05 March 2020

Ilias Iliopoulos ,
Matthew N. Alder ,
David S. Cooper ,
Enrique G. Villarreal Open the ORCID record for Enrique G. Villarreal [Opens in a new window] ,
Rohit Loomba Open the ORCID record for Rohit Loomba [Opens in a new window] ,
Rashmi D. Sahay ,
Lin Fei ,
Paul E. Steele  and
Saul Flores
Ilias Iliopoulos
Affiliation:
Department of Pediatrics, The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Matthew N. Alder
Affiliation:
Division of Critical Care, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
David S. Cooper
Affiliation:
Department of Pediatrics, The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Enrique G. Villarreal*
Affiliation:
Instituto Tecnologico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo Leon, Mexico Department of Pediatrics, Section of Critical Care Medicine, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA
Rohit Loomba
Affiliation:
Department of Pediatrics, Division of Advocate Children’s Hospital/Chicago Medical School, Chicago, IL, USA
Rashmi D. Sahay
Affiliation:
Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Lin Fei
Affiliation:
Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Paul E. Steele
Affiliation:
Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Saul Flores
Affiliation:
Department of Pediatrics, Section of Critical Care Medicine, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA
*
Author for correspondence: E. G. Villarreal, MD, Research Scholar, Cardiac Intensive Care Unit, Section of Critical Care and Cardiology at Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA. Tel: +1 312 282 6935. Fax: +832 825 2969. E-mail: quique_villarreal93@hotmail.com
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Abstract

Neutrophil–lymphocyte ratio has been associated with clinical outcomes in several groups of cardiac patients, including patients with coronary artery disease, cardiac failure, and cardiac transplant recipients. We hypothesised that pre- and/or post-operative haematological cell counts are associated with clinical outcomes in children undergoing cardiac surgery for CHD. We performed a post hoc analysis of data collected as part of a prospective observational cohort study (n = 83, data available n = 47) of children evaluated for glucocorticoid receptor levels after cardiac surgery (July 2015–January 2016). The association of neutrophil–lymphocyte ratio with low cardiac output syndrome, time to inotrope free, and vasoactive-inotropic score was examined using proportional odds analysis, cox regression, and linear regression models, respectively. A majority (80%) of patients were infants (median/interquartile range 4.1/0.2–7.6 months) with conotruncal (36%) and left-sided obstructed lesions (28%). Two patients required mechanical circulatory support and three died. Higher pre-operative neutrophil–lymphocyte ratio was associated with higher cumulative odds of severe/moderate versus mild low cardiac output on post-operative day 1 (odds ratio 2.86; 95% confidence interval 1.18–6.93; p = 0.02). Pre-operative neutrophil–lymphocyte ratio was not significantly associated with time to inotrope free or vasoactive-inotrope score. Post-operative neutrophil–lymphocyte ratio was also not associated with outcomes. In children after congenital heart surgery, higher pre-operative neutrophil–lymphocyte ratio was associated with a higher chance of low cardiac output in the early post-operative period. Pre-operative neutrophil–lymphocyte ratio maybe a useful prognostic marker in children undergoing congenital heart surgery.

Keywords

Neutrophil–lymphocyte ratiohemographic indicespaediatric cardiac surgerylow cardiac outputcardiac intensive care
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 4 , April 2020 , pp. 521 - 525
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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