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Assessment of cardiac function and electrocardiographic findings in patients with Wilson’s disease

Published online by Cambridge University Press:  28 August 2019

Asuman N. Karhan Open the ORCID record for Asuman N. Karhan [Opens in a new window] ,
Hayrettin H. Aykan Open the ORCID record for Hayrettin H. Aykan [Opens in a new window] ,
Ersin Gümüş Open the ORCID record for Ersin Gümüş [Opens in a new window] ,
Yasemin Dönmez ,
Dursun Alehan ,
Süheyla Özkutlu ,
Hülya Demir Open the ORCID record for Hülya Demir [Opens in a new window] ,
İnci N. Saltık Temizel Open the ORCID record for İnci N. Saltık Temizel [Opens in a new window] ,
Hasan Özen Open the ORCID record for Hasan Özen [Opens in a new window]  and
Aysel Yüce
Asuman N. Karhan*
Affiliation:
Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Hayrettin H. Aykan
Affiliation:
Department of Paediatrics, Division of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Ersin Gümüş
Affiliation:
Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Yasemin Dönmez
Affiliation:
Department of Paediatrics, Division of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Dursun Alehan
Affiliation:
Department of Paediatrics, Division of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Süheyla Özkutlu
Affiliation:
Department of Paediatrics, Division of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Hülya Demir
Affiliation:
Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
İnci N. Saltık Temizel
Affiliation:
Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Hasan Özen
Affiliation:
Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Aysel Yüce
Affiliation:
Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
*
Author for correspondence: A. N. Karhan, Department of Paediatrics, Division of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. E-mail: asunurkar83@gmail.com
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Abstract

Background:

This study evaluated cardiac function using tissue Doppler echocardiography and assessed electrocardiographic findings in children diagnosed with Wilson’s disease.

Method:

Asymptomatic patients with a diagnosis of Wilson’s disease (n = 43) were compared to healthy controls (n = 37) that were age and gender matched.

Results:

The standard electrocardiographic and conventional echocardiographic examinations were similar in both groups. The left ventricular ejection fraction, shortening fraction, and diastolic function were not significantly different between the two groups. The Tei index for mitral lateral, mitral septal, tricuspid lateral, tricuspid septal, and inter-ventricular septum on tissue Doppler echocardiography was higher in the patient group, yet it did not reach statistical significance. Mitral lateral and septal systolic annular velocity values were significantly lower in the patient group when compared to the control group (p = 0.02 and 0.04, respectively). Also, mitral lateral and septal isovolumetric contraction time values were higher in the patient group (p = 0.04). Although the left ventricular values were not significantly different, relative left ventricular wall thickness was higher in the patient group when compared to the control group, and concentric remodelling in the left ventricle was found in 7 (16%) of 42 patients. QT interval (p = 0.02) and P-wave dispersion values (p = 0.04) were significantly higher in the patient group compared to the control group, and these tend to predict arrhythmias.

Conclusion:

Our study based on the tissue Doppler echocardiography assessment indicated a subclinical systolic, rather than diastolic, dysfunction in the myocardium with increased QT interval and P-wave dispersion, despite the young age of the patients and short disease duration.

Keywords

Wilson’s diseasecardiac evaluationchildhood
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 9 , September 2019 , pp. 1183 - 1188
Copyright
© Cambridge University Press 2019 

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