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Assessment of the effects of physiological release of melatonin on arterial distensibility and blood pressure

Published online by Cambridge University Press:  01 April 2009

Mustafa Yildiz  and
Osman Akdemir
Mustafa Yildiz*
Affiliation:
Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Educational and Research Hospital, Istanbul, Turkey
Osman Akdemir
Affiliation:
Department of Cardiology, Acibadem Health Care Group, Istanbul, Turkey
*
Correspondence to: Dr Mustafa Yildiz, Bayar Cad., Gülbahar Sok., Emniyet Sitesi No:11, A Blok A Kapısı Daire 6, Kozyatagi-Istanbul, Turkey. Tel: 90 532 371 17 01; Fax: 90 216 459 63 21; E-mail: mustafayilldiz@yahoo.com
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Abstract

Aim

The aim of our study was to investigate the effects of endogenous melatonin on arterial distensibility using measurements of the velocity of the aortic pulse wave between the carotid and femoral arteries in healthy young students assessed in the supine position.

Material and methods

We studied 29 healthy young students, aged between 18 and 27 years, with 19 being male. The measured the velocity of the aortic pulse wave between the carotid and femoral arteries, along the blood pressures and heart rate, while the subjects were in the supine position at two time points, namely from 01.30–02.30 and 13:30–14:30 hours, during a day, also taking plasma to measure the concentrations of melatonin. The velocity of the pulse waves was determined using an automatic device, the Complior Colson (France), which allowed on-line recording and automatic calculation of the velocity, the calculations being made by measuring the transit time of the pulse wave as it traversed the distance between two sites of recording according, the velocity of the pulse wave in meter per second being equal to the distance in meters divided by the time of transit in seconds.

Results

Although the velocity of the pulse wave, systolic, diastolic, and mean blood pressures, and heart rate were all increased in the morning relative to measurement made later in the day, levels of melatonin in the plasma were increased in the night. There was negative correlation between diurnal levels of melatonin and the velocity of the pulse wave.

Conclusion

Our findings indicate that increased levels of melatonin during the night may cause a decreased velocity of the aortic pulse wave, along with blood pressures and heart rate.

Keywords

Pulse wave velocitydiurnal rhythm
Type
Original Article
Information
Cardiology in the Young , Volume 19 , Issue 2 , April 2009 , pp. 198 - 203
Copyright
Copyright © Cambridge University Press 2009

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