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Association between N-terminal pro-brain natriuretic peptide and quality of life in adult patients with congenital heart disease

Published online by Cambridge University Press:  21 November 2013

John O. Younge ,
Jannet A. Eindhoven ,
Elisabeth W. M. J. Utens ,
Petra Opić ,
Judith A. A. E. Cuypers ,
Annemien E. van den Bosch ,
Maarten Witsenburg ,
Ron T. van Domburg ,
M. G. Myriam Hunink  and
Jolien W. Roos-Hesselink
John O. Younge
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Clinical Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Jannet A. Eindhoven
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
Elisabeth W. M. J. Utens
Affiliation:
Department of Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands
Petra Opić
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
Judith A. A. E. Cuypers
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
Annemien E. van den Bosch
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
Maarten Witsenburg
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
Ron T. van Domburg
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
M. G. Myriam Hunink
Affiliation:
Department of Clinical Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Jolien W. Roos-Hesselink*
Affiliation:
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
*
Correspondence to: J. W. Roos-Hesselink, Department of Cardiology, Ba-583, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. Tel: +31(0)10 7032432; Fax:+31(0)10 7035498; E-mail: j.roos@erasmusmc.nl
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Abstract

Aims: Advances in medical treatment have resulted in increased life expectancy in congenital heart disease. Consequently, the focus of management has shifted from reducing mortality to reducing long-term morbidity with the goal of improving quality of life. A predictor of quality of life might be N-terminal pro-brain natriuretic peptide, a well-established marker for heart failure. We aimed to determine the association between N-terminal pro-brain natriuretic peptide and quality of life in patients with congenital heart disease. Methods: We collected blood samples from consecutive patients who were initially operated between 1968 and 1980 (47.8% women; mean age 40.2±5.4 years). The 36-item Short-Form Health Survey was completed to assess subjective health status as a measure of quality of life. Analysis was performed for the entire group and for subgroups defined as simple versus complex congenital heart diseases. Median N-terminal pro-brain natriuretic peptide level was 15.2 pmol/L (overall range 1.3–299.3 pmol/L). N-terminal pro-brain natriuretic peptide levels were associated with the subdomain physical functioning (β=−0.074, p=0.031). This association remained significant after adjustment for age and sex (β=−0.071, p=0.038) and after adjustment for age, sex, body mass index, left ventricular function, and renal function (β=−0.069, p=0.048). In complex congenital heart disease, the association between N-terminal pro-brain natriuretic peptide and physical functioning remained significant in multivariable analysis (β=−0.076, p=0.046). No associations were found in the simple congenital heart disease group or on the other health status subdomains. Conclusion: In adults operated for congenital heart disease, N-terminal pro-brain natriuretic peptide is associated with the subdomain physical, primarily in the complex subgroup.

Keywords

Congenital heart diseasequality of lifenatriuretic peptides
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 2 , February 2015 , pp. 288 - 294
Copyright
Copyright © Cambridge University Press 2013 

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