Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-25T18:35:46.208Z Has data issue: false hasContentIssue false
  • English
  • Français

Association of matrix metalloproteinase 3 and γ-glutamyltransferase 1 gene polymorphisms with the cardio-ankle vascular index in young Russians

Published online by Cambridge University Press:  10 May 2016

Alexander V. Sorokin ,
Kazuhiko Kotani  and
Olga Y. Bushueva
Alexander V. Sorokin*
Affiliation:
Department of Internal Medicine, Kursk State Medical University, Kursk, Russia
Kazuhiko Kotani
Affiliation:
Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan
Olga Y. Bushueva
Affiliation:
Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russia
*
Correspondence to: A. Sorokin, MD, PhD, Department of Internal Medicine, Kursk State Medical University, K. Marx St.3, 305041, Kursk, Russia. Tel: +7 (4712) 58 8132; Fax: +7 (4712) 56 7399; E-mail: drsorokin@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Specific gene polymorphisms are known to be associated with a different arterial physiology in the younger generation. The present study found that young Russians with the matrix metalloproteinase 3 6A/6A and γ-glutamyltransferase 1AA genotypes have lower levels of the cardio-ankle vascular index – a recent measure of arterial stiffness. This observation may serve as an additional tool for cardiovascular disease prevention in the young population.

Keywords

Arterial stiffnesscardio-ankle vascular indexmatrix metalloproteinasestromelysin-1γ-glutamyltransferasepolymorphism
Type
Brief Reports
Information
Cardiology in the Young , Volume 26 , Issue 6 , August 2016 , pp. 1238 - 1240
Check for updates
Copyright
© Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Natarajan, P, O’Donnell, CJ. Reducing cardiovascular risk using genomic information in the era of precision medicine. Circulation 2016; 133: 1155–1159.Google Scholar
2. Sorokin, A, Kotani, K, Bushueva, O, Taniguchi, N, Lazarenko, V. The cardio-ankle vascular index and ankle-brachial index in young Russians. J Atheroscler Thromb 2015; 22: 211–218.Google Scholar
3. Sorokin, AV, Kotani, K, Bushueva, OY, Polonikov, AV. Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians. Cardiol Young 2016; 26: 677–682.Google Scholar
4. Beilby, JP, Chapman, CM, Palmer, LJ, McQuillan, BM, Thompson, PL, Hung, J. Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population. J Hypertens 2005; 23: 537–542.Google Scholar
5. El-Aziz, TA, Mohamed, RH. Matrix metalloproteinase 3 gene polymorphism and its level predict morbidity after acute myocardial infarction. Am J Clin Pathol 2016; 145: 134–139.Google Scholar
6. Medley, TL, Kingwell, BA, Gatzka, CD, Pillay, P, Cole, TJ. Matrix metalloproteinase-3 genotype contributes to age-related aortic stiffening through modulation of gene and protein expression. Circ Res 2003; 92: 1254–1261.CrossRefGoogle ScholarPubMed
7. Dahboul, F, Leroy, P, Maguin Gate, K, et al. Endothelial γ-glutamyltransferase contributes to the vasorelaxant effect of S-nitrosoglutathione in rat aorta. PLOS ONE 2012; 7: e43190.Google Scholar
8. Jung, CH, Yu, JH, Bae, SJ, et al. Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals. Clin Endocrinol (Oxf) 2011; 75: 328–334.Google Scholar
9. Kweon, SS, Shin, MH, Nam, HS, et al. Dose-response relationship between serum gamma-glutamyltransferase and arterial stiffness in Korean adults: the Namwon Study. J Epidemiol 2014; 24: 7–14.Google Scholar
10. Li, Y, Iso, H, Cui, R, et al. Serum gamma-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women. J Atheroscler Thromb 2016.Google ScholarPubMed