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CHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes

Published online by Cambridge University Press:  08 September 2015

Benjamin J. Landis ,
David S. Cooper  and
Robert B. Hinton
Benjamin J. Landis*
Affiliation:
Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
David S. Cooper
Affiliation:
Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Robert B. Hinton
Affiliation:
Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
*
Correspondence to: B. J. Landis, MD, Division of Pediatric Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America. Tel: 317 278 2807; Fax: 317 274 8679; E-mail: benjland@iu.edu
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Abstract

CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes – for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.

Keywords

CHDsyndromegenetic
Type
Review Articles
Information
Cardiology in the Young , Volume 26 , Supplement 1 , January 2016 , pp. 30 - 52
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Copyright
© Cambridge University Press 2015 

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Table S2

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Table S3

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Table S4

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Table S5

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Table S6

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