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Clinical impact of subcutaneous treprostinil in trisomy 21 patient with pulmonary arterial hypertension associated with CHD

Published online by Cambridge University Press:  10 January 2022

Ryusuke Numata Open the ORCID record for Ryusuke Numata [Opens in a new window] ,
Kiyohiro Takigiku  and
Kouta Takei
Ryusuke Numata*
Affiliation:
Department of Pediatric Cardiology, Nagano Children’s Hospital, Nagano, Japan
Kiyohiro Takigiku
Affiliation:
Department of Pediatric Cardiology, Nagano Children’s Hospital, Nagano, Japan
Kouta Takei
Affiliation:
Department of Pediatric Cardiology, Nagano Children’s Hospital, Nagano, Japan
*
Author for correspondence: R. Numata, Department of Pediatric Cardiology, Nagano Children’s Hospital, Azumino, Nagano 8288, Japan. Tel: +81-263-73-6700; Fax: +81-263-73-555. E-mail: k054eb@gmail.com
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Abstract

Subcutaneous treprostinil is commonly used to improve idiopathic pulmonary arterial hypertension in children. However, its effectiveness has not been reported in trisomy 21. We report the case of 9-year-old boy in trisomy 21 with CHD-pulmonary artery hypertension after surgical correction of CHD. Haemodynamics and exercise capacity dramatically improved with a transition from oral selexipag to subcutaneous treprostinil.

Keywords

Pulmonary artery hypertensiontreprostiniltrisomy 21congenital heart disease
Type
Brief Report
Information
Cardiology in the Young , Volume 32 , Issue 9 , September 2022 , pp. 1502 - 1504
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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