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A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study

Published online by Cambridge University Press:  18 July 2013

Li Chen ,
Xueying Li ,
Ochs Todd ,
Cheng Wang ,
Hongfang Jin  and
Junbao Du
Li Chen
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Xueying Li
Affiliation:
Department of Statistics, Peking University First Hospital, Beijing, China
Ochs Todd
Affiliation:
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States ofAmerica
Cheng Wang
Affiliation:
The Second Hospital of Xiangya, Zhongnan University, Changsha, China
Hongfang Jin*
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Junbao Du
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
*
Correspondence to: H. Jin, Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Tel: +8610 83573209; Fax: +8610 66530532; E-mail: jinhongfang51@126.com
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Abstract

Objective: At present, the haemodynamic diagnosis of orthostatic intolerance is based mainly on the head-up tilt table test, which is sometimes risky for patients. Thus, it is important to find objective and safe methods to differentiate haemodynamic patterns of orthostatic intolerance cases. Methods: In all, 629 children with orthostatic intolerance, either vasovagal syncope or postural orthostatic tachycardia syndrome, were included in the multi-centre clinical study. We analysed the association between the clinical manifestation and haemodynamic patterns of the patients. Results: Syncope after motion with a prodrome of chest distress or palpitations and the concomitant symptom(s) after a syncopal attack, with debilitation, dizziness or headache, were the most important variables in predicting the diagnosis of vasovagal syncope. The overall diagnostic accuracy was 71.5%. Conclusion: Complaint of syncope after motion with prodromal chest distress or palpitation and the concomitant symptom after a syncopal attack, with subsequent debilitation, dizziness or headache, were the most important variables in the diagnosis of vasovagal syncope in children with orthostatic intolerance.

Keywords

Discriminationvasovagal syncopepostural orthostatic tachycardia syndrome
Type
Original Articles
Information
Cardiology in the Young , Volume 24 , Issue 4 , August 2014 , pp. 649 - 653
Copyright
Copyright © Cambridge University Press 2013 

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