Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-10T05:15:43.107Z Has data issue: false hasContentIssue false
  • English
  • Français

COVID-19 in children: acute endotheliopathy, but forgotten prostacyclin replacement?

Published online by Cambridge University Press:  21 June 2021

Dietmar Schranz Open the ORCID record for Dietmar Schranz [Opens in a new window]
Dietmar Schranz*
Affiliation:
Johann-Wolfgang-Goethe University Clinic, Frankfurt, Germany
*
Author for correspondence: Prof. Dr. Dietmar Schranz, Pediatric Heart Center, Johann-Wolfgang Goethe University Clinic, Theodor-Stern-Kai 7, 60590Frankfurt, Germany. E-mails: dietmar.schranz@kgu.de; dietmar.schranz@paediat.med.uni-giessen.de
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 4 , April 2022 , pp. 572 - 573
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Sendzikaite, S, Heying, R, Milanesi, O, Hanseus, K, Michel-Behnke, I. Covid-19 FAQs in paediatric and congenital cardiology: AEPC position paper. CY 2021, doi: 10.1017/S1047951120005028.CrossRefGoogle Scholar
Feigenbaum, DC, June, CH. Cytokine storm. N Engl J Med 2020; 383 (23): 2255–2273.doi: 10.1056/NEJMra2026131.CrossRefGoogle Scholar
Wu, C, Chen, X, Cai, Y, et al. Risk factors associated with acute respiratory distress syndrome and Death in patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med 2020; 180 (7): 934–943. doi: 10.1001/jamainternmed.2020.0994. Erratum in: JAMA Intern Med. 2020 Jul 1;180(7):1031. PMID: 32167524; PMCID: PMC7070509.CrossRefGoogle ScholarPubMed
Varga, Z, Flammer, AJ, Steiger, P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 2020; 395: 1417–1418. doi: 10.1016/S0140-6736 (20) 30937-5.CrossRefGoogle ScholarPubMed
Viner, RM, Whittaker, E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet 2020; 395 (10239): 1741–1743.10.1016/S0140-6736(20)31129-6CrossRefGoogle ScholarPubMed
Swann, OV, Holden, KA, Turtle, L, et al. Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ 2020; 370: m3249. doi: 10.1136/bmj.m3249. PMID: 32960186; PMCID: PMC7488201.CrossRefGoogle Scholar
Ramanathan, M, Ferguson, ID, Miao, W, Khavari, PA. SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity. Lancet Infect Dis 2021: S1473–3099(21)00262–0. doi: 10.1016/S1473-3099(21)00262-0. Epub ahead of print. PMID: 34022142.CrossRefGoogle ScholarPubMed
ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic 2020. https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance.Google Scholar
Klingel, K, Sauter, M, Bock, CT, Szalay, G, Schnorr, JJ, Kandolf, R. Molecular pathology of inflammatory cardiomyopathy. Med Microbiol Immunol 2004; 193 (2–3): 101–107.10.1007/s00430-003-0190-1CrossRefGoogle ScholarPubMed
Hu, H, Ma, F, Wei, X, Fang, Y. Coronavirus fulminant myocarditis saved with glucocorticoid and human immunoglobulin. Eur Heart J 2020; 42 (2), 7 January 2021, Page 191, https://doi.org/10.1093/eurheartj/ehaa248.Google Scholar
Tavazzi, G, Pellegrini, C, Maurelli, M, et al. Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail 2020; 22: 911–915.10.1002/ejhf.1828CrossRefGoogle ScholarPubMed
Lowenstein, CJ, Solomon, SD. Severe COVID-19 Is a Microvascular Disease. Circulation 2020; 142: 1609–1611. DOI: 10.1161/CIRCULATIONAHA.120.050354.10.1161/CIRCULATIONAHA.120.050354CrossRefGoogle ScholarPubMed
Swann, OV, Holden, KA, Turtle, L, et al. Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ 2020; 370: m3249. doi: 10.1136/bmj.m3249. PMID: 32960186; PMCID: PMC7488201.CrossRefGoogle Scholar
Onofrio, L, Caraglia, M, Facchini, G, Margherita, V, De Placido, S, Buonerba, C. Toll-like receptors and COVID-19: a two-faced story with an exciting ending. Future Sci OA 2020; 6 (8): FSO605. doi: 10.2144/fsoa-2020-0091.CrossRefGoogle ScholarPubMed
Gladka, MM, Maack, C. The endothelium as Achilles’ heel in COVID-19 patients. Cardiovasc Res 2020; 116 (14): e195–e197. doi: 10.1093/cvr/cvaa327.CrossRefGoogle ScholarPubMed
Tang, N, Li, D, Wang, X, Sun, Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020; 18: 844–847.10.1111/jth.14768CrossRefGoogle ScholarPubMed
Sarkar, C, Mondal, M, Torequl Islam, M, et al. Potential Therapeutic Options for COVID-19: current Status, Challenges, and Future Perspectives. Front Pharmacol 2020; 11: 572870. Published 2020 Sep 15. doi: 10.3389/fphar.2020.572870.CrossRefGoogle ScholarPubMed
Weiss, SL, Peters, MJ, Alhazzani, W, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med 2020; 46 (Suppl 1): S10–S67. https://doi.org/10.1007/s00134-019-05878-6.CrossRefGoogle ScholarPubMed
Mueller, FM, Ehrenthal, W, Hafner, G, Schranz, D. Purpura fulminans in severe congenital protein C deficiency: monitoring of treatment with protein C concentrate. Eur J Pediatr 1996; 155: 20–25.CrossRefGoogle Scholar
Johansson, PI, Bestle, M, Søe-Jensen, P, Kristiansen, KT, Stensballe, J, Clausen, NE, Perner, A. The effect of prostacyclin (Iloprost) infusion at a dose of 1 ng/kg/min for 72 hours compared to placebo in mechanically ventilated patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial. Trials 2020; 21: 746. https://doi.org/10.1186/s13063-020-04696-2.CrossRefGoogle Scholar
Viecca, M, Radovanovic, D, Forleo, GB, Santu, P. Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study. Pharmacol Res 2020; 158: 104950.CrossRefGoogle ScholarPubMed
McCrindle, BW, Rowley, AH, Newburger, JW, et al.; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Epidemiology and Prevention. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association Circulation 2017; 135 (17): e927–e999; [published correction appears in Circulation. 2019;140(5): e181–e184].CrossRefGoogle ScholarPubMed