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Dimensions of the pulmonary arteries in rat fetuses with congenital heart disease

Published online by Cambridge University Press:  19 August 2008

Kazuo Momma ,
Masahiko Ando  and
Masaaki Yoshigi
Kazuo Momma*
Affiliation:
From the Department of Pediatric Cardiology, The Heart Institute ofJapan, Tokyo Women's Medical College, Tokyo
Masahiko Ando
Affiliation:
From the Department of Pediatric Cardiology, The Heart Institute ofJapan, Tokyo Women's Medical College, Tokyo
Masaaki Yoshigi
Affiliation:
From the Department of Pediatric Cardiology, The Heart Institute ofJapan, Tokyo Women's Medical College, Tokyo
*
Dr. Kazuo Momma, Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College, 8–1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan. Tel. 03-3353-8111; Fax. 03-3356-0441.
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Abstract

So as to understand better the pathogenesis of enlargement or hypoplasia of pulmonary arteries in congenital heart disease, we studied the dimensions of the pulmonary arteries in 74 fetuses with congenital heart disease induced by administration of bis-diamine to pregnant rats. The congenital malformations induced included 12 with large ventricular septal defect, 17 with tetralogy of Fallot, 15 with tetralogy together with severe valvar pulmonary stenosis and absence of the arterial duct, 17 with tetralogy with absent pulmonary valve syndrome and absence of the arterial duct, and 13 with common arterial trunk with a confluent segment supplying the pulmonary arteries. For comparison, 16 fetuses of the same gestational age with normal hearts were studied. After rapid whole-body freezing on the 21st day of gestation, the fetuses were studied by means of serial cross-sectional photographs of the thorax. The diameter of the right pulmonary artery of the fetus was of comparable dimensions in the normal hearts (480±10 µm) (mean±SEM), those with ventricular septal defects (470±10 µm), common arterial trunk (520±20 µm), and tetralogy of Fallot (500±10 µm). These findings suggest that the commonly observed enlargement of the right pulmonary artery in patients with ventricular septal defect and common arterial trunk, and hypoplasia of the right pulmonary artery in tetralogy of Fallot, occur postnatally in response to abnormal postnatal pulmonary blood flow.

Keywords

Fetuspulmonary arterytetralogy of Fallotabsent pulmonary valvecommon arterial trunkventricular sepral defect
Type
Original Articles
Information
Cardiology in the Young , Volume 4 , Issue 3 , July 1994 , pp. 291 - 297
Copyright
Copyright © Cambridge University Press 1994

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References

Wagenvoort, CA, Wagenvoort, N.Pathology of Pulmonary Hypertension. John Wiley & Sons, New York, 1977, pp 56–94.Google Scholar
Van Praagh, R, Ando, M, Van Praagh, S, Senno, A, Hougen, TJ, Novak, G, Hastreiter, AR. Pulmonary atresia: Anatomic considerations. In: Kidd, BSL, Rowe, RD (eds). The Child with Congenital Heart Disease after Surgery. Futura Publishing Co., Mount Kisco, NY, 1976, pp 103–134.Google Scholar
Rudolph, AM.Congenital Diseases of the Heart. Year Book Medical Publishers, Inc., Chicago, 1974, pp 29–48.Google Scholar
Allan, LD, Sharland, GK.Prognosis in fetal tetralogyof Fallot. Pediatr Cardiol 1992; 13: 1–4.CrossRefGoogle ScholarPubMed
Cartier, MS, Davidoff, A, Warneke, LA, Hirsh, MP, Bannon, S, StJohn Sutton, M, Doubiler, PM.The normal diameter of the fetal aorta and pulmonary artery: Echocardiographic evaluation in utero. Am J Roentgenol 1987; 149: 1003–1007.CrossRefGoogle ScholarPubMed
Angelini, A, Allan, LD, Anderson, RH, Crawford, DC, Chita, S, Ho, SY.Measurements of the dimensions of the aortic and pulmonary pathways in the human fetus: a correlative echocardiographic and morphometric study. Br Heart J 1988; 60: 221 –226.CrossRefGoogle ScholarPubMed
Hornberger, LK, Weintraub, RG, Pesonen, E, Murillo-Olivas, A, Simpson, IA, Sahn, C, Hagen-Ansert, S, Sahn, DJ.Echocardiographic study of the morphology and growth of the aortic arch in the human fetus. Observation related to the prenatal diagnosis of coarctation. Circulation 1992; 86:741–747.CrossRefGoogle Scholar
Taleporos, P, Salgo, MP, Oster, C.Teratogenic action of a bis (dichloroacetyl) diamine on rats: patterns of malformations produced in high incidence at time-limited periods of development. Teratology 1978; 18: 5–16.CrossRefGoogle ScholarPubMed
Momma, K, Takao, A, Ito, R, Nishikawa, T.In situ morphology of the heart and great vessels in fetal and newborn rats. Pediatr Res 1987; 22: 573–580.CrossRefGoogle ScholarPubMed
Momma, K, Takao, A.Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rats. Circ Res 1989; 64: 1137–1146.CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Takao, A.Fetal cardiac morphology of tetralogy of Fallot with absent pulmonary valve in the rat. Circulation 1990; 82: 1343–1351.CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Mori, Y, Ito, T.Hypoplasia of the lung and heart in fetal rats with diaphragmatic hernia. Fetal Diagn Ther 1992; 7: 46–52.CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Takao, A, Fen-Fen, Wu.Fetal cardiovascular morphology of tetralogy of Fallot in rats. Fetal Diagn Ther 1990: 5: 196–.204CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Takao, A, Miyagawa-Tomita, S.Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat. Circulation 1991; 83: 2094–2100.CrossRefGoogle ScholarPubMed
Collett, RW, Edwards, JE.Persistent truncus arreriosus: A classification according to anatomic types. Surg Clin N Amer 1949; 29: 1245–1270.CrossRefGoogle ScholarPubMed
Danilowicz, DA, Rudolph, AM, Hoffman, JIE, Heymann, M.Physiologic pressure differences between main and branch pulmonary arteries in infants. Circulation 1972; 45:410–419.CrossRefGoogle ScholarPubMed
Haworth, SG. Pulmonary vasculature development. In: Long, WA (ed). Fetal and Neonatal Cardiology, W.B. Saunders, Philadelphia, 1990, pp 51–63.Google Scholar
Haworth, SG, Reid, L.Quantitative structural study of pulmonary circulation in the newborn with pulmonary atresia Thorax. 1977; 32: 129–133.CrossRefGoogle ScholarPubMed
Haworth, SG, Reid, L.Quantitative structural study of pulmonary circulation in the newborn with aortic atresia, stenosis, or coarctation. Thorax 1977; 32: 121–128.CrossRefGoogle ScholarPubMed
Rosenthal, A, Bank, ER. Ventricular septal defect. In: Moller, JH, Neil, WA (eds). Fetal, Neonatal, and Infant Cardiac Disease. Appleton & Lange, Norwalk, CN, 1990, pp 371– 390.Google Scholar
Stanger, P. Truncus arteriosus. In: Moller, JH, Neil, WA (eds). Fetal, Neonatal, and Infant Cardiac Disease. Appleton & Lange, Norwalk, CN, 1990, pp 371–390.Google Scholar
Mair, DD, Edwards, WD, Hagler, DJ, Jusland, PR, Puga, FJ. Tetralogy of Fallot and pulmonary atresia with ventricular septal defect. In: Moller, JH, Neil, WA (eds). Fetal, Neonatal, and Infant Cardiac Disease. Appleton & Lange, Norwalk, CN, 1990, pp 639–670.Google Scholar
Fouron, J-C, Sahn, DJ, Bender, R, Block, R, Schneider, H, Fromberger, P, Hagen-Ansert, S, Daily, PO.Prenatal diagnosis and circulatory characteristics in tetralogy of Fallot and absent pulmonary valve. Am J Cardiol 1989; 64: 547–549.CrossRefGoogle ScholarPubMed