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Endothelial function state following repair of cyanotic congenital heart diseases

Published online by Cambridge University Press:  29 October 2013

Mohammad Reza Sabri ,
Hooman Daryoushi  and
Mojgan Gharipour
Mohammad Reza Sabri
Affiliation:
Child Growth and Development Research Center, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Hooman Daryoushi*
Affiliation:
Department of Pediatrics, School of Medicine, Felowship in Pediatric Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mojgan Gharipour
Affiliation:
Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
*
Correspondence to: Dr H. Daryoushi, MD, Department of Pediatrics, School of Medicine, Felowship in Pediatric Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: mojgangharipour@gmail.com
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Abstract

Background

Repairing cyanotic congenital heart disease may be associated with preserving endothelial function. The present study aimed to evaluate vascular endothelial function in patients with repaired cyanotic congenital heart disease.

Methods

In a case–control study conducted in 2012 in Isfahan, Iran, 42 consecutive patients aged <35 years who had suffered from different types of cyanotic congenital heart disease and had undergone complete repair of their congenital heart defect were assessed in regard to their endothelial function state by measuring flow-mediated dilatation and other cardiac function indices. They were paired with 42 sex- and age-matched healthy controls.

Results

The mean flow-mediated dilatation was lower in patients with repaired cyanotic congenital heart disease than in the controls [6.14±2.78 versus 8.16±1.49 respectively (p<0.001)]. Significant adverse correlations were found between flow-mediated dilatation, age, and body mass indexes, in those who underwent repair surgery. In addition, flow-mediated dilatation had a positive association with the shortening fraction, ejection fraction, and tricuspid annular plane systolic excursion value, and it was also inversely associated with carotid intima-media thickness and the myocardial performance index. The mean of the flow-mediated dilatation was significantly higher in the group with tetralogy of Fallot along with complete repair before the age of 2.5 years and also in those patients with total anomalous pulmonary venous connection or transposition of the great arteries repaired with an arterial switch operation before 6 months of age, compared with the other two subgroups. This includes patients with a tetralogy of Fallot defect repaired after 4 years of age and those with complex cyanotic congenital heart disease that was repaired after 2.5 years of age (mean age at repair 9±6.1 years).

Conclusion

Early repair of a cyanotic defect can result in the protection of vascular endothelial function and prevent the occurrence of vascular accidents at an older age.

Keywords

Endothelial functioncongenitalcyanoticheart diseaserepair
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 2 , February 2015 , pp. 222 - 227
Copyright
Copyright #x00A9; Cambridge University Press 2013 

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