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Evaluation of arterial stiffness and central blood pressure by oscillometric method in normotensive offspring of hypertensive parents

Published online by Cambridge University Press:  13 August 2021

Cansu Sivrikaya Yildirim ,
Pelin Kosger Open the ORCID record for Pelin Kosger [Opens in a new window] ,
Tugcem Akin Open the ORCID record for Tugcem Akin [Opens in a new window]  and
Birsen Ucar
Cansu Sivrikaya Yildirim
Affiliation:
Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
Pelin Kosger
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
Tugcem Akin*
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
Birsen Ucar
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
*
Author for correspondence: T. Akin, MD, Pediatric Cardiologist, Faculty of Medicine, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey. Tel: +905316748195; Fax: +902222393772. Email: doktorakin67@gmail.com
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Abstract

Children with a family history of hypertension have higher blood pressure and hypertensive pathophysiological changes begin before clinical findings. Here, the presence of arterial stiffness was investigated using central blood pressure measurement and pulse wave analysis in normotensive children with at least one parent with essential hypertension. Twenty-four-hour ambulatory pulse wave analysis monitoring was performed by oscillometric method in a study group of 112 normotensive children of hypertensive parents aged between 7 and 18 comparing with a control group of 101 age- and gender-matched normotensive children of normotensive parents. Pulse wave velocity, central systolic and diastolic blood pressure, systolic, diastolic and mean arterial blood pressure values were higher in the study group than the control group (p < 0.001, p = 0.002, p = 0.008, p = 0.001, p = 0.005, p = 0.001, p = 0.001, respectively). In all age groups (7–10, 11–14, and 15–18 years), pulse wave velocity was higher in the study group than the control group (p < 0.001). Pulse wave velocity was higher in children whose both parents are hypertensive compared to the children whose only mothers are hypertensive (p = 0.011). Pulse wave velocity values were positively correlated with age, weight, height, and body mass index (p < 0.05). Higher pulse wave velocity, central systolic and diastolic blood pressure values detected in the study group can be considered as early signs of hypertensive vascular changes. Pulse wave analysis can be a reliable, non-invasive, and reproducible method that can allow taking necessary precautions regarding lifestyle to prevent disease and target organ damage by detecting early hypertensive changes in genetically risky children.

Keywords

Aortic pressurechildheredityhypertensionpulse wave analysis
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 6 , June 2022 , pp. 888 - 895
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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