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Insulin resistance surrogates and left ventricular hypertrophy in normotensive obese children

Part of: Metabolic Echocardiography

Published online by Cambridge University Press:  22 March 2021

Ljiljana Bjelakovic ,
Vladimir Vukovic Open the ORCID record for Vladimir Vukovic [Opens in a new window] ,
Sanja Stankovic Open the ORCID record for Sanja Stankovic [Opens in a new window] ,
Milan Ciric ,
Stevo Lukic ,
Milovan Bratic ,
Sasa Pantelic ,
Ljiljana Saranac  and
Bojko Bjelakovic Open the ORCID record for Bojko Bjelakovic [Opens in a new window]
Ljiljana Bjelakovic
Affiliation:
Department of medical science, Faculty of Sport and Physical Education, University of Nis, Nis, Serbia
Vladimir Vukovic
Affiliation:
Centre for Disease Control and Prevention, Institute of Public Health of Vojvodina, Novi Sad, Serbia
Sanja Stankovic
Affiliation:
Center for Medical Biochemistry, University Clinical Center of Serbia, Belgrade, Serbia
Milan Ciric
Affiliation:
Medical Faculty, University of Nis, Nis, Serbia
Stevo Lukic
Affiliation:
Clinic of Neurology, Clinical Center, Nis, Serbia, Medical Faculty, University of Nis, Nis, Serbia
Milovan Bratic
Affiliation:
Department of medical science, Faculty of Sport and Physical Education, University of Nis, Nis, Serbia
Sasa Pantelic
Affiliation:
Department of medical science, Faculty of Sport and Physical Education, University of Nis, Nis, Serbia
Ljiljana Saranac
Affiliation:
Clinic of Pediatrics, Clinical Center, Nis, Serbia, Medical Faculty, University of Nis, Nis, Serbia
Bojko Bjelakovic*
Affiliation:
Clinic of Pediatrics, Clinical Center, Nis, Serbia, Medical Faculty, University of Nis, Nis, Serbia
*
Author for correspondence: Bojko Bjelakovic MD, Ph.D. Associate Prof., Clinic of Pediatrics, Clinical Center, Nis, Zorana Djindjica 48 Boulevard, 18000 Nis, Serbia. Tel: +381652083321; Fax: +381184234190. E-mail: bojko968@gmail.com
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Abstract

Background:

The relationship between different surrogates of insulin resistance and left ventricular geometry in obese children is still unclear.

Objective:

We sought to explore the relationship between commonly used measures of insulin sensitivity/resistance (homeostatic model assessment index, serum uric acid, and triglycerides to high-density lipoprotein cholesterol ratio) and left ventricular geometry in normotensive obese children.

Methods:

In this cross-sectional study, 32 normotensive obese children were examined. Transthoracic echocardiography was used to measure left ventricular mass index and relative wall thickness. Homeostasis model assessment index, serum uric acid level, and a ratio of triglycerides to high-density lipoprotein cholesterol were used as markers of the insulin resistance. Simple and partial correlation analyses (to control for the effects of body mass index) were conducted to explore relationship between studied variables and left ventricular mass index or relative wall thickness as outcome variables.

Results:

We found positive correlations between homeostasis model assessment index and relative wall thickness (r = 0.47, p = 0.03) which remained significant after controlling for the effect of body mass index, z-score (r = 0.48, p = 0.03). The cutoff level of homeostasis model assessment index with the optimum sensitivity (Sn) and specificity (Sp) derived from the receiver operating characteristic (ROC) curves for predicting concentric remodelling was ≥5.51 with Sn = 83.33 and Sp = 68.75.

Conclusion:

There is a positive relationship between homeostasis model assessment index and relative wall thickness of obese normotensive children which may help to distinguish at risk obese normotensive children for the development of concentric left ventricular remodelling.

Keywords

Obesityinsulin resistancechildrenleft ventricular mass indexrelative wall thickness
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 12 , December 2021 , pp. 1901 - 1906
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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