Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-10T12:18:16.019Z Has data issue: false hasContentIssue false
  • English
  • Français

Levosimendan as a bridge to heart transplant in a 16-year-old patient with univentricular heart

Published online by Cambridge University Press:  23 July 2020

Magdalena Mazurak Open the ORCID record for Magdalena Mazurak [Opens in a new window] ,
Paweł Cześniewicz  and
Jacek Kusa
Magdalena Mazurak*
Affiliation:
Department of Pediatric Cardiology, Regional Specialist Hospital, Research and Development Center, Wroclaw, Poland
Paweł Cześniewicz
Affiliation:
Department of Pediatric Cardiology, Regional Specialist Hospital, Research and Development Center, Wroclaw, Poland
Jacek Kusa
Affiliation:
Department of Pediatric Cardiology, Regional Specialist Hospital, Research and Development Center, Wroclaw, Poland
*
Author for correspondence: Magdalena Mazurak, MD, PhD, Wojewódzki Szpital Specjalistyczny, ul. Kamieńskiego 73a, 51-124Wroclaw, Poland. Tel: +48691509787; Fax: +48713254101. E-mail: madzia-mazurak@wp.pl
Get access Rights & Permissions [Opens in a new window]

Abstract

We report the successful use of levosimendan in the treatment of heart failure in a patient with the univentricular heart. The presented case was atypical because our patient had systemic right ventricle. To our knowledge, it is the first reported such case with intermittent levosimendan administration as an effective treatment and bridge to successful heart transplant in a patient with functionally univentricular heart.

Keywords

Levosimendansingle ventriclehypoplastic left heart syndromeFontan pathwayheart failuresystemic right ventricle
Type
Brief Report
Information
Cardiology in the Young , Volume 30 , Issue 10 , October 2020 , pp. 1504 - 1506
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Delgado, JF, Oliva, F, Reinecke, A. The inodilator levosimendan in repetitive doses in the treatment of advanced heart failure. Eur Heart J 2017; 19 (Suppl C): C8–C14.Google ScholarPubMed
Silvetti, S, Nieminen, MS. Repeated or intermittent levosimendan treatment in advanced heart failure: an updated meta-analysis. Int J Cardiol 2016; 202: 138–143.CrossRefGoogle ScholarPubMed
Malfatto, G, Della Rosa, F, Villani, A, et al. Intermittent levosimendan infusions in advanced heart failure: favourable effects on left ventricular function, neurohormonal balance, and one-year survival. J Cardiovasc Pharmacol 2012; 60: 450–455.Google ScholarPubMed
Oliva, F, Comin-Colet, J, Fedele, F, et al. Repetitive levosimendan treatment in the management of advanced heart failure. Eur Heart J Suppl 2018; 20 (Suppl I): I11–I20. doi: 10.1093/eurheartj/suy040 CrossRefGoogle ScholarPubMed
Follath, F, Cleland, JG, Just, H, et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 2002; 360: 196–202.CrossRefGoogle ScholarPubMed
Tavares, J, Baptista, B, Sarmento, P, Goncalves, B, Abecassis, M. Levosimendan in single ventricle heart failure after longterm survival of a modified blalock-taussig shunt. Rev Port Cir Cardiotorac Vasc 2019; 26: 147–149.Google ScholarPubMed
Iacobelli, R, Ricci, Z, Marinari, E, et al. Effects of levosimendan on ventriculo-arterial coupling and cardiac efficiency in paediatric patients with single-ventricle physiology after surgical palliation: retrospective study. Interact Cardiovasc Thorac Surg 2020; 30: 623–629. doi:10.1093/icvts/ivz319 CrossRefGoogle Scholar
Hansen, MS, Andersen, A, Nielsen-Kudsk, JE. Levosimendan in pulmonary hypertension and right heart failure. Pulm Circ 2018; 8: 2045894018790905. doi: 10.1177/2045894018790905 CrossRefGoogle ScholarPubMed
Wang, YB, Hao, GZ, Jiang, YF, et al. Effects of levosimendan on right ventricular function in patients with acute decompensated heart failure. Acta Cardiol Sin 2019; 35: 585–591. doi: 10.6515/ACS.201911_35(6).20190327A Google ScholarPubMed
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. EHJ 2016; 37: 2129–2200. doi: 10.1093/eurheartj/ehw128 Google Scholar