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MicroRNAs: a new piece in the paediatric cardiovascular disease puzzle

Published online by Cambridge University Press:  26 February 2013

Ahmed Omran ,
Dalia Elimam ,
Keith A. Webster ,
Lina A. Shehadeh  and
Fei Yin
Ahmed Omran
Affiliation:
Department of Pediatrics and Neonatology, Suez Canal University, Ismailia, Egypt Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, Hunan, China
Dalia Elimam
Affiliation:
Department of Pediatrics and Neonatology, Suez Canal University, Ismailia, Egypt
Keith A. Webster
Affiliation:
Vascular Biology Institute, Department of Molecular and Cellular Pharmacology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America
Lina A. Shehadeh
Affiliation:
Interdisciplinary Stem Cell Institute, Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America
Fei Yin*
Affiliation:
Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, Hunan, China
*
Correspondence to: Dr F. Yin, MD, PhD, Department of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China. Tel: +86-13517492323; Fax: +86-731-84327922; E-mail: Yf_2323@yahoo.com
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Abstract

Cardiovascular diseases in children comprise a large public health problem. The major goals of paediatric cardiologists and paediatric cardiovascular researchers are to identify the cause(s) of these diseases to improve treatment and preventive protocols. Recent studies show the involvement of microRNAs (miRs) in different aspects of heart development, function, and disease. Therefore, miR-based research in paediatric cardiovascular disorders is crucial for a better understanding of the underlying pathogenesis of the disease, and unravelling novel, efficient, preventive, and therapeutic means. The ultimate goal of such research is to secure normal cardiac development and hence decrease disabilities, improve clinical outcomes, and decrease the morbidity and mortality among children. This review focuses on the role of miRs in different paediatric cardiovascular conditions in an effort to encourage miR-based research in paediatric cardiovascular disorders.

Keywords

MicroRNAspaediatric cardiovascular diseasesbiomarkertherapeutic targetcardiac stem cells
Type
Review Articles
Information
Cardiology in the Young , Volume 23 , Issue 5 , October 2013 , pp. 642 - 655
Copyright
Copyright © Cambridge University Press 2013 

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