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Myocardial performance after successful intervention for native aortic coarctation

Published online by Cambridge University Press:  13 January 2010

Vedide Tavli ,
Turkay Saritas ,
Baris Guven ,
Faik Okur ,
Berna Cevik Saylan ,
Talat Tavli ,
Bekir Sami Uyanik ,
Zeki Ari  and
Banu İsbilen
Vedide Tavli
Affiliation:
Izmir Dr Behcet Uz Children’s Hospital, Pediatric Cardiology, Izmir, Turkey
Turkay Saritas
Affiliation:
Siyami Ersek Hospital, Paediatric Cardiology, Istanbul, Turkey
Baris Guven*
Affiliation:
Izmir Dr Behcet Uz Children’s Hospital, Pediatric Cardiology, Izmir, Turkey
Faik Okur
Affiliation:
Sifa Medical Center, Cardiothoracic Surgery, Izmir, Turkey
Berna Cevik Saylan
Affiliation:
Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Pediatric Cardiology, Ankara, Turkey
Talat Tavli
Affiliation:
Celal Bayar University, Cardiology, Manisa, Turkey
Bekir Sami Uyanik
Affiliation:
Celal Bayar University Hospital, Biochemistry, Manisa, Turkey
Zeki Ari
Affiliation:
Celal Bayar University Hospital, Biochemistry, Manisa, Turkey
Banu İsbilen
Affiliation:
Celal Bayar University Hospital, Biochemistry, Manisa, Turkey
*
Correspondence to: Baris Guven MD, Izmir Dr Behcet Uz Children’s Hospital, Pediatric Cardiology, Izmir, Turkey 1417 Street Alsancak/Izmir Zip code: 35210. Tel: +90 2324895656-2210; Fax: +90 2324892315; E-mail: drbarisguven@yahoo.com
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Abstract

Coarctation of the aorta is associated with increased risk for hypertension in adulthood, despite successful repair. The intrinsic mechanisms underscoring hypertension and left ventricular performance in these patients, however, remains to be determined. Our objective was to evaluate left ventricular performance by means of echocardiographic and biochemical parameters at midterm follow-up in normotensive children who have had undergone successful surgical or catheter interventional treatment of coarctation with a residual gradient of less than 20 mmHg at rest. We studied prospectively 14 patients with native aortic coarctation who underwent surgery or balloon angioplasty, the cohort made up of equal numbers of boys and girls, and having a mean age of 8.5 plus or minus 4 years. We also studied 30 age-matched healthy subjects, measuring mitral inflow pulsed wave signals, isovolumic relaxation and contraction times, myocardial performance index parameters, and levels of B-type natriuretic peptide and endothelin-1 in both groups. We found no differences in systolic blood pressure at rest between the patients and their controls. The ventricular septal diastolic dimensions, left ventricular posterior wall dimensions, mitral valve E wave, deceleration time, isovolumic relaxation time, isovolumic contraction time and myocardial performance index were all significantly increased in the patients. Levels of plasma B-type natriuretic peptide and endothelin-1 were also significantly higher in the patients when compared to the control group. We conclude that aortic coarctation is a chronic disease characterized by persistency of myocardial and vascular alterations. The elevated levels of plasma b-type natriuretic peptide and endothelin-1 may be indicative of late onset hypertension after successful treatment of native coarctation in early childhood.

Keywords

Balloon dilationendothelin-1B-type natriuretic peptide
Type
Original Articles
Information
Cardiology in the Young , Volume 20 , Issue 1 , February 2010 , pp. 33 - 38
Copyright
Copyright © Cambridge University Press 2010

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